Benzyl derivatives and pesticides containing them

ABSTRACT

Benzyl derivatives of the formula I ##STR1## where A is CH 2 , CHCl, CH-alkyl, CH-alkoxy, CH-alkylthio or N-alkoxy, 
     B is OH, alkylthio, alkoxy or alkylamino, 
     U, V, W are hydrogen, halogen, alkyl or alkoxy, 
     D is ##STR2## where R&#39; is hydrogen or alkyl and 
     R is hydrogen, alkyl, cycloalkyl, haloalkyl, halocycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, arylthioalkyl, aryloxyalkyl, aryl, arylalkyl, hetaryl, hetaryl-alkyl, hetaryloxyalkyl or heterocyclyl, and fungicides containing these compounds.

This is a Continuation of application Ser. No. 08/099,692 filed on Jul. 30. 1993, now U.S. Pat. No. 5,416,110.

The present invention relates to novel benzyl derivatives and pesticides for controlling pests, in particular fungi, insects, nematodes and spider mites. It is known that certain β-methoxyacrylates (cf. European Patent 178,826) as well as certain oxime ethers (cf. European Patent 253,213) have fungicidal or insecticidal activity. However, their action is unsatisfactory.

We have found, surprisingly, that benzyl derivatives of the general formula I ##STR3## where A is CH₂, CHCl, CH--C₁ -C₄ -alkyl, CH--C₁ -C₄ -alkoxy, CH--C₁ C₄ -alkylthio or N--C₁ -C₄ -alkoxy,

B is OH, C₁ -C₄ -alkylthio, C₁ -C₄ -alkoxy or C₁ -C₄ -alkylamino,

U, V and W are identical or different and are each hydrogen, halogen, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy,

D is ##STR4## where R' is hydrogen or C₁ -C₄ -alkyl,

R is hydrogen, C₁ -C₁₀ -alkyl, C₃ -C₆ -cycloalkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -halocycloalkyl, C₃ -C₆ -cycloalkyl-C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl, unsubstituted or substituted arylthio-C₁ -C₄ -alkyl, unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryl, unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl or unsubstituted or substituted heterocyclyl, substituents being halogen, cyano, CO₂ (C₁ -C₄ -alkyl) , CO(C₁ -C₄ -alkyl), nitro, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy, C₁ -C₄ -alkoximino-C₁ - or C₂ -alkyl, aryl, aryloxy, benzyloxy, hetaryl, hetaryloxy, C₃ -C₆ -cycloalkyl, heterocyclyl or heterocyclyloxy, have an excellent fungicidal, insecticidal, nematicidal and acaricidal action which is better than that of the known β-methoxyacrylates or oxime ethers. The fungicidal action is preferred.

The radicals stated for the general formula I may have, for example, the following meanings:

A may be C₁ -C₄ -alkylidene (eg. methylidene, ethylidene, n-propylidene, isopropylidene, n-butylidene, isobutylidene, sec-butylidene or tert-butylidene), C₁ -C₄ -alkoxymethylidene (eg. methoxy-, ethoxy-, n-propoxy-, isopropoxy-, n-butoxy-, isobutoxy-, sec-butoxy- or tert-butoxymethylidene), C₁ -C₄ -alkylthiomethylidene (eg. methyl-, ethyl-, n-propyl-, isopropyl-, n-butyl-, isobutyl-, sec-butyl- or tert-butyl-thiomethylidene), C₁ -C₄ -alkoximino (eg. methoximino, ethoximino, n-propoximino, isopropoximino, n-butoximino, isobutoximino, sec-butoximino or tert-butoximino or chloromethylidene,

B may be OH, C₁ -C₄ -alkoxy (eg. methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy or tert-butoxy), C₁ -C₄ -alkylthio (eg. methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio or tert-butylthio) and C₁ -C₄ -alkylamino (eg. methylamino, ethylamino, n-propylamino, isopropylamino, n-butylamino, isobutylamino, sec-butylamino or tert-butylamino),

U, V and W may each be H, halogen (eg. fluorine, chlorine, bromine or iodine), methyl or methoxy,

D may be ##STR5## R' may be hydrogen or C₁ -C₄ -alkyl (eg. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl) and

R may be straight-chain or branched C₁ -C₁₀ -alkyl (eg. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, sec-pentyl, tert-pentyl, neopentyl, n-hexyl or n-decyl),

C₃ -C₆ -cycloalkyl (eg. cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl), C₁ -C₄ -haloalkyl (eg. trifluoromethyl, 2-fluoroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, fluorodichloromethyl, difluorochloromethyl, chloromethyl, trichloromethyl, 2-chloroethyl, 2,2,2-trichloroethyl or pentachloroethyl), C₃ -C₆ -halocycloalkyl (eg. 2,2-difluorocyclopropyl, 2,2-dichlorocyclopropyl, 2,2-dibromocyclopropyl, 2,2-dichloro-3-methylcyclopropyl or tetrafluorocyclobutyl), C₃ -C₆ -cycloalkyl-C₁ -C₄ -allyl (eg. 1-methylcyclopropyl, 2,2-dimethylcyclopropyl or 1-methylcyclohexyl), C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl (eg. methoxymethyl, ethoxymethyl, n-propoxylmethyl, isopropoxylmethyl, n-butoxymethyl, isobutoxymethyl, sec-butoxymethyl, tert-butoxymethyl, 2-methoxyprop-2-yl, 2-ethoxyprop-2-yl, 2-n- or isopropoxyprop-2-yl, 2-n-, iso-, sec- or tert-butoxyprop-2-yl), C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl (eg. methylthiomethyl, ethylthiomethyl, n-propylthiomethyl, isopropylthiomethyl, n-butylthiomethyl, isobutylthiomethyl, sec-butylthiomethyl, tert-butylthiomethyl, 2-methylthioprop-2-yl,2-ethylthioprop-2-yl, 2-n- or isopropylthioprop-2-yl, 2-n-, iso-, sec- or tert-butylthioprop-2-yl), aryl(phenyl)thio-C₁ -C₄ -alkyl (eg. phenylthiomethyl or 2-chlorophenylthiomethyl),

unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl (eg. phenoxymethyl),

unsubstituted or substituted aryl (eg. phenyl, naphthyl or anthryl),

unsubstituted or substituted aryl-C₁ -C₄ -alkyl (eg. benzyl, 1-phenethyl, 2-phenethyl, 1-phenylpropyl, 2-phenylpropyl, 3-phenylpropyl, 2-methyl-3-phenylpropyl, 2-methyl-2-phenylpropyl or 4-phenylbutyl),

unsubstituted or substituted hetaryl (eg. pyridyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidinyl, 4-pyrimidinyl, 2-pyrimidinyl, thienyl, 2-thienyl, 3-thienyl, furyl, 2-furyl, 3-furyl, 1-pyrrolyl, 1-imidazolyl, 1,2,4-triazolyl, 1,3,4-triazolyl, 4-thiazolyl or 2-benzothiazolyl),

unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl (eg. 2-pyridylmethyl or 3-pyridylmethyl),

unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl (eg. furfurylmethoxy) or

unsubstituted or substituted heterocyclyl (eg. oxiranyl, 1-aziridinyl, 1-azetidinyl, 1-pyrrolidinyl, 2-tetrahydrofuryl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 1-piperidinyl, 1-morpholinyl, 1-piperazinyl, 1,3-dioxanyl or 3-tetrahydrothiopyranyl).

The radicals referred to as being unsubstituted or substituted above are substituted, apart from hydrogen, for example by fluorine, chlorine, bromine, iodine, cyano, nitro, methyl, ethyl, isopropyl, tert-butyl, methoxy, ethoxy, isopropoxy, tert-butoxy, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, trifluoromethoxy, 1,1,2,2-tetrafluoroethoxy, methoximinomethyl, ethoximinomethyl, n-propoximinomethyl, n-butoximinomethyl n-pentyloximinomethyl, n-hexyloximinomethyl, allyloximinomethyl, benzyloximinomethyl, isopropoximinomethyl, isobutoximinomethyl, tert-butoximinomethyl, methylimino-1-ethyl, ethoximino-1-ethyl, n-propoximino-1-ethyl, n-butoximino-1-ethyl, n-pentyloximino-1-ethyl, n-hexyloximino-1-ethyl, allyloximino-1-ethyl, benzyloximino-1-ethyl, phenyl, phenoxy, benzyloxy, imidazol-1-yl, piperazin-1-yl, 4-morpholinyl, piperidin-1-yl, pyrid-2-yloxy, cyclopropyl, cyclohexyl, oxiranyl, 1,3-dioxan-2-yl, 1,3-dioxolan-2-yl or tetrahydropyran-2-yloxy.

Preferred compounds of the general formula I are those in which

A is CHCH₃, CHCH₂ CH₃, CHOCH₃ or NOCH₃,

B is OCH₃ or NHCH₃,

U, V and W are each hydrogen,

R' is hydrogen and methyl or

D and R each have the meanings stated in claim 1.

Owing to the C═C or C═N double bonds, the novel compounds of the general formula I may be obtained in the preparation as E/Z isomer mixtures. These can be separated into the individual components in a conventional manner, for example by crystallization or chromatography. Both the individual isomeric compounds and mixtures thereof form subjects of the invention and can be used as pesticides.

The preparation of the compounds of the general formula I as claimed in claim I is carried out, for example, as described in Scheme 1. ##STR6##

The compounds of the general formula I where A is CH₂, CH-Alkyl or CH-Alkoxy can be prepared, for example, from the ketoester 4 by a Wittig or Wittig-Horner reaction (cf. European Patents 348,766 or 178,826 or German Patent 3,705,389). The similar compounds 5 are obtained from the ketoesters 2 in the same manner.

In an alternative procedure, a compound of the formula 7 or 9 is condensed with a suitable reagent, for example with formaldehyde where A is CH₂ (cf. German Patent 3,317,356), a) with an aldehyde (cf. D. M. Brown, J. Chem. Soc. (1948), 2147) or b) first with N,N-dimethylformamide dimethyl acetal followed by reaction with a Grignard reagent where A is CH-Alkyl (similarly to C. Jutz, Chem. Ber. 91 (1958), 1867), with a formate followed by alkylation where A is CH-O-Alkyl (cf. European Patent 178,826). Further preparation methods for the compounds of the formula 5 and I where A is CH-O-Alkyl are described in European Patent 178,826.

A further possibility for the preparation of the compounds of the formula I where A is CH-Alkyl and B is O-Alkyl is the reaction of ketene acetals with phenyl chlorocarbonates (cf. N. Slougui, G. Rousseau, Synth. Commun. 12 (5) (1982), 401-407).

For compounds of the general formula I where A is CH-S-Alkyl and A is CHCl, the preparation can be carried out by the methods from European Patent 244,077 or 310,954.

The intermediates of the formulae 3, 6 and 8 can be prepared from the compounds 2, 5 and 7 by halogenating the latter by known methods, for example with chlorine, bromine or N-bromosuccinimide in an inert solvent (eg. CCl₄ or cyclohexane) with exposure to, for example, an vapor lamp or using a free radical initiator, such as dibenzoyl peroxide, or by introducing the radicals L, such as mesylate, rosylate, acetate or triflate, via suitable intermediates (L is halogen or

The oxime ethers of the formula I where A is N-O-Alkyl can be prepared from 4 a) by reaction with an O-Alkylhydroxylamine hydrochloride or b) with hydroxylamine hydrochloride and subsequent alkylation with an alkylating agent (eg. an alkyl iodide, dialkyl sulfate, etc.) (cf. German Patent 3,623,921).

Using the methods similar to that in European Patent 254,426, a phenylacetate of the formula 9 can be converted with a base (eg. NaOMe, NaH, K tert-butylate, etc.) in a solvent (such as diethyl ether, toluene, tert-butanol, etc.) into its anion and can be oximated with a suitable nitrosating agent (such as methyl nitrite, amyl nitrite, tert-butyl nitrite, etc.). The resulting oximate is alkylated with an alkylating agent (eg. an alkyl iodide or dialkyl sulfate).

The same methods can also be applied to the compounds of the formulae 2 and 7, and the resulting oxime ethers 5 can be converted in a known manner (European Patent 254,426) via the intermediates 6 (L is, for example, halogen) into the desired compounds I.

The novel compounds of the general formula I are obtained specifically by reacting a benzyl derivative having a suitable leaving group L (eg. halogen) 6 with a carbonic acid salt 10 in an inert solvent or diluent. ##STR7##

Specifically, the novel compounds are obtained as follows: ##STR8## Trithiocarbonates 13 are obtained, for example, by reacting the metal salts 12 with the benzyl bromides 11 by methods similar to known ones (cf. for example Houben-Weyl, Vol. E 4, page 451 et seq. (1983)). ##STR9##

The dithiocarbonates 15 can be prepared, for example, by reacting the benzyl bromides 11 with the metal salts 14 by methods similar to known ones (cf. for example R. Degani, Synthesis, (1975), 365). ##STR10##

Dithiocarbamates of the type 17 are obtained, for example, in the reaction with the benzyl bromides 11 with the compounds 16 by methods similar to known ones (cf. for example Houben-Weyl, Vol. E 4, page 299 et seq. (1983)). ##STR11##

The dithiocarbonic acid derivatives 18 may be obtained by thermal or acid-catalyzed rearrangement from the dithiocarbonic acid derivatives 15 (cf. for example Houben-Weyl, Vol. E 4, page 133 et seq. (1983)). ##STR12##

The thiocarbonates 20 are prepared, for example, by reaction of the benzyl bromides 11 with thiocarbonates 19 analogously to known processes (cf. for example Houben-Weyl Vol. E 4, page 108 et seq. (1983)). ##STR13##

Thiocarbamic acids 22 are accessible by reaction of the benzyl bromides 11 with metal salts 21 analogously to known processes (cf. for example Houben-Weyl, Vol. E 4, page 299 (1983)). ##STR14##

Carbonic diesters 24 are obtained by methods similar to known ones, by reacting the benzyl bromides 11 with carbonates 23 (cf. for example V. F. Pozdner, Zh. Org. Khim. 12 (1976), 1407). ##STR15##

The carbamates 26 are obtainable by methods similar to known ones, from the benzylbromides 11 and the phosphacarbamates 25 (cf. for example M. Aresta, JOC 53 (1988), 4153).

The carboxylic acid metal salts 12, 14, 16, 19, 21, 23 and 25 are known or can be prepared by methods known from the literature (cf. Houben-Weyl, Vol. E 4).

In the preparation processes described above, B is usually alkoxy and U, V and W are each usually H.

The compounds in which B is OH (28) can be prepared by methods known from the literature (Organikum 16th Edition, pages 415 and 622), from the compounds of the general formula I where B is O-Alkyl (27) (cf. Scheme 2): ##STR16##

The acyl chlorides 29 can be prepared from the resulting carboxylic acids 28 in a conventional manner (cf. Organikum 16th Edition, page 423 et seq. (1985)). The conversion of 29 into the amides 30 is carried out similarly to Organikum 16th Edition, page 412 (1985).

The thioesters 31 are obtained from the acyl chlorides 29 (similarly to Houben-Weyl, Vol. 8, page 464 et seq. (1952)).

Alternatively, the thioesters 31 can also be obtained from the acids 28 (similarly to Houben-Weyl, Vol. E5, page 855 et seq. (1985)).

The amides 30 can also be prepared from the esters 27 by methods known from the literature.

The preparation of the compounds of the general formulae 2 and 7 which are ortho-substituted by methyl on the aromatic moiety is known (B is O-Alkyl and U, V and W are each H; cf. European Patents 178,826 and 260,832).

The reactions described can be carried out, for example, in an inert solvent or diluent (eg. acetone, acetonitrile, dimethylformamide, dimethyl sulfoxide or N-methylpyrrolidone) using a base (eg. sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride or sodium methylate).

The reaction can also be carried out in a two-phase system (eg. dichloromethane, water) with the addition of a suitable phase transfer catalyst (eg. cetyltrimethylammoniumchloride or benzyltriethylammonium chloride).

EXAMPLES EXAMPLE 1 Methyl 2-methoximino-2-{2-[(methyl-4-methylphenylthiocarbamoylsulfonyl)-methyl]-phenyl}-acetate (compound No. 157 in Table 2)

A pinch of potassium iodide is added to a solution of 3.6 g (17.5 mmol) of sodium N-methyl-N-4-methylphenyldithiocarbamate and 5 g (17.5 mmol) of methyl 2-methoximino-2-(2'-bromomethyl)-phenylacetate in 50 ml of acetone and stirring is carried out for 15 hours at room temperature. Thereafter, the mixture is filtered under suction and the mother liquor is evaporated down. The residue is stirred in ether and filtered off under suction. 4.6 g (65%) of compound No. 157 (Table 2) remain as a colorless solid.

m.p.: 109°-113° C.

¹ H-NMR (CDCl₃ /TMS): δ=2.35; 3.72; 3.77; 3.97 (each s, 3H, CH₃); 4.30 (hr, 2H, CH₂); 7.07-7.47 ppm (m, 8H, aryl-H).

EXAMPLE 2 Preparation of compound 157, Table 4

1 g (2.5 mmol) of the compound prepared in Example 1 is heated with 50 ml of 40% strength N-methylamine solution for 2 hours at 40° C. Extraction is then carried out three times with ether, and the combined organic phases are dried and evaporated down. 1 g of the N-methylamide compound (No. 157, Table 4) remains as a colorless solid.

¹ H-NMR (CDCl₃ /TMS): δ=2.35; 3.72; 3.88 (each s, 3H, CH₃); 2.89 (d, 3H, NHCH₃); 4.32, (s, 2H, CH₂); 6.67 (br, 1H, NH); 7.05-7.43 ppm (m, 8H, aryl-H).

EXAMPLE 3 Preparation of compound No. 157, Table 1

A pinch of potassium iodide is added to a solution of 1.4 g (7 mmol) of sodium N-methyl-N-4-methylphenyldithiocarbamate and 2 g (7 mmol) of methyl α-(2-bromomethylphenyl)-β-methoxyacrylate in 50 ml of acetone and stirring is carried out for 16 hours at room temperature. Thereafter, the mixture is filtered under suction and the mother liquor is evaporated down. The remaining residue is chromatographed over silica gel using hexane/methyl tert-butyl ether. 1.2 g (43%) of compound No. 157 (Table 1) are obtained as a colorless solid.

mp.: 98°-99° C.

¹ H-NMR (CDCl₃ /TMS): δ=2.33; 3.57; 3.74 (each s, 3H, CH₃); 4.35 (s, 2H, CH₂); 7.05-7.43 (m, 8H, aryl-H); 7.51 (s, 1H, ═CH).

EXAMPLE 4 Preparation of 2-hydroxymethyl-α-methoxyiminophenylacetic acid monomethylamide

A mixture of 57 g (200 mmol) of methyl 2-methoximino-2-(2-bromomethyl)phenylacetate, 29 g (300 mmol) of potassium acetate and a spatula tip of potassium iodide is heated in 300 ml of dimethylformamide for 30 minutes at 90° C. After the mixture has cooled it is stirred into ice water. The precipitate is filtered with suction, washed with water and dried; colorless crystals, mp. 70°-72° C., yield 50 g (94% of theory).

The compound thus obtained (50 g/188 mmol) is dissolved in 500 ml of THF, 100 ml (1.12 mol) of 40% strength aqueous methylamine solution are added and the mixture is stirred for 22 hours at room temperature. The mixture is evaporated down, and the residue is taken up in ethyl acetate, washed twice with saturated sodium chloride solution, dried over magnesium sulfate and evaporated down. The oily residue gradually solidifies on standing; the product crystallizes on trituration with diisopropyl ether/ligroin. Beige-colored crystals, mp. 99°-103° C., yield 32 g (82% of theory).

¹ H-NMR (CDCl₃ /δ scale): 2.90 (d, 3H, NCH₃); 3.48 (br t, 1H, OH); 2, 3H, OCH₃); 4.40 (d, 2H, CH₂ O); 7.05 (br, 1H, NH); 7.14 (dd, 1H) and 7.2-7.6 (m, 3H, aromatic protons)

IR (KBr, ˜ in cm⁻¹): 3384, 3306, 3281, 1647, 1035

EXAMPLE 5 Preparation of 2-(4-fluoroanilinocarbonyloxymethyl)-α-methoxyiminophenylacetic acid monomethylamide (Comp. 293, Tab. 4)

a) 2.2 g (10 mmol) of the compound obtained in Example 4, 1.4 g (10 mmol) of 4-fluorophenyl isocyanate and a spatula tip of 4-N,N-dimethylaminopyridine are stirred in 150 ml of toluene for 4 hours at 100° C. The product precipitates out on cooling. It is filtered with suction, washed with toluene and dried. Colorless crystals, mp. 208°-209° C., yield 2.4 g (67% of theory). The compound is a 3:1 mixture of two rotamers.

¹ H-NMR (CDCl₃ /δ scale): 2.81 and 2.90 (2d, tog. 3H, NCH₃ in both rotamers); 3.96 and 4.01 (2s, tog. 3H, OCH₃); 5.08 and 5.36 (2s, tog. 2H, OCH₂); 6.7-7.5 (several multiplets, tog. 10H, aromatic protons and both NH).

b) 2.2 g (10 mmol) of the compound obtained in Example 4 were suspended in 200 ml of toluene and heated to 60° C.; first 1.74 g (10 mmol) of 4-fluorophenyl chloroformate and then 1.5 ml (1.1 g/10 mmol) of triethylamine were added dropwise. The mixture was stirred for 2 hours and allowed to cool, the precipitate was filtered with suction, the filtrate was washed several times with water, dried over magnesium sulfate and evaporated down. 3.0 g (83% of theory) of the compound (No. 293; Tab. 4) were obtained.

The compounds shown in the Tables below are prepared according to the Examples described.

                                      TABLE 1                                      __________________________________________________________________________      ##STR17##                                                                     No.                                                                               D      R' R                   phys. data.sup.a)                             __________________________________________________________________________     1  SC(S)NR'R                                                                             CH.sub.3                                                                          methyl                                                            2  SC(S)NR'R                                                                             CH.sub.3                                                                          ethyl                                                             3  SC(S)NR'R                                                                             CH.sub.3                                                                          n-propyl                                                          4  SC(S)NR'R                                                                             CH.sub.3                                                                          tert.-butyl                                                       5  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclopropyl                                                       6  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclohexyl          3.70, 3.85(3H), 4.50(2H), 7.63(1H)            7  SC(S)NR'R                                                                             CH.sub.3                                                                          methoxymethyl                                                     8  SC(S)NR'R                                                                             CH.sub.3                                                                          phenoxymethyl                                                     9  SC(S)NR'R                                                                             CH.sub.3                                                                          methylthiomethyl                                                  10 SC(S)NR'R                                                                             CH.sub.3                                                                          phenyl              3.55; 3.71; 3.76(3 × 3H);                                                4.37(2H);                                                                      7.03-7.40(9H); 7.51(1H)                       11 SC(S)NR'R                                                                             CH.sub.3                                                                          2-fluorophenyl                                                    12 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluorophenyl      102-106° C.                            13 SC(S)NR'R                                                                             CH.sub.3                                                                          4-fluorophenyl      3.57; 3.73; 3.74(3 × 3H);                                                4.35(2H);                                                                      7.04-7.43(8H), 7.51(1H)                       14 SC(S)NR'R                                                                             CH.sub.3                                                                          pentafluorophenyl                                                 15 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorophenyl                                                    16 SC(S)NR'R                                                                             CH.sub.3                                                                          3-chlorophenyl      3.57; 3.72; 3.74(3 × 3H);                                                4.34(2H);                                                                      7.04-7.43(8H); 7.51(1H)                       17 SC(S)NR'R                                                                             CH.sub.3                                                                          4-chlorophenyl      3.00, 3.71, 3.86(3H), 4.35(2H)                18 SC(S)NR'R                                                                             CH.sub.3                                                                          pentachlorophenyl                                                 19 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3-dichlorophenyl                                                20 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dichlorophenyl                                                21 SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dichlorophenyl                                                22 SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dichlorophenyl                                                23 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dichlorophenyl                                                24 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dichlorophenyl                                                25 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trichlorophenyl                                             26 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trichlorophenyl                                             27 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trichlorophenyl                                             28 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             29 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichlorophenyl                                             30 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trichlorophenyl                                             31 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         32 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         33 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     34 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     35 SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     36 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 37 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            38 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           39 SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      40 SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      41 SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      42 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           43 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           44 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-6-fluorophenyl                                           45 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            46 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            47 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-fluorophenyl                                            48 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            49 SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-fluorophenyl                                           50 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           51 SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     52 SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     53 SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     54 SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     55 SC(S)NR'R                                                                             CH.sub.3                                                                          3-nitrophenyl                                                     56 SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     57 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl      2.17; 3.54; 3.69; 3.71; (4 × 3H);                                        4.35(2H); 7.03-7.41(8H); 7.51(1H)             58 SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl      2.34; 3.65; 3.72; 3.74; (4 × 3H);                                        4.36(2H); 7.00-7.51(8H); 7.43(1H)             59 SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl      98-99° C.                              60 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                61 SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl  120-121° C.                            62 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                63 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                64 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             65 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             66 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             67 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             68 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             69 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethylphenyl                                             70 SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 71 SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     72 SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     73 SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     74 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 75 SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  76 SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  77 SC(S)NR'R                                                                             CH.sub. 3                                                                         4-n-propylphenyl                                                  78 SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropylphenyl                                                 79 SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropylphenyl                                                 80 SC(S)NR'R                                                                             CH.sub.3                                                                          4-isopropylphenyl                                                 81 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-diisopropylphenyl                                             82 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diisopropylphenyl                                             83 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-butyphenyl                                                    84 SC(S)NR'R                                                                             CH.sub.3                                                                          4-sec.-butylphenyl                                                85 SC(S)NR'R                                                                             CH.sub.3                                                                          4-iso-butylphenyl                                                 86 SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylphenyl                                               87 SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butylphenyl                                               88 SC(S)NR'R                                                                             CH.sub.3                                                                          2-tert.-butylphenyl                                               89 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-di-tert.-butylphenyl                                          90 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-di-tert.-butylphenyl                                          91 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-hexylphenyl                                                   92 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-dodecylphenyl                                                 93 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-tert.-butylphenyl                                      94 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-tert.-butylphenyl                                      95 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropylphenyl                                        96 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-cyclohexylphenyl                                       97 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenylphenyl                                           98 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzylphenyl                                           99 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenoxyphenyl                                          100                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzyloxyphenyl                                        101                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-chlorophenyl                                           102                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-chlorophenyl                                           103                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-chlorophenyl                                           104                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-chlorophenyl                                           105                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-fluorophenyl                                           106                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-bromophenyl                                            107                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-bromophenyl                                            108                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-methoxyphenyl                                          109                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoxyphenyl                                          110                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-methoxyphenyl                                          111                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-methoxyphenyl                                          112                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropoxyphenyl                                       113                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-2,5-dimethoxyphenyl                                      114                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methoxyphenyl                                                   115                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methoxyphenyl                                                   116                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methoxyphenyl                                                   117                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3-dimethoxyphenyl                                               118                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethoxyphenyl                                               119                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dimethoxyphenyl                                               120                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethoxyphenyl                                               121                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethoxyphenyl                                               122                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethoxyphenyl                                               123                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,6-dimethoxyphenyl                                               124                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethoxyphenyl                                            125                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethoxyphenyl                                            126                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethoxyphenyl                                            127                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             128                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichlorophenyl                                             129                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         130                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         131                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     132                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     133                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     134                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 135                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            136                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           137                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      138                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      139                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      140                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           141                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           142                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-6-fluorophenyl                                           143                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            144                                                                               SC(S)NR' R                                                                            CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            145                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-fluorophenyl                                            146                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-chlorophenyl                                            147                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-fluorophenyl                                           148                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           149                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     150                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     151                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     152                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     153                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-nitrophenyl                                                     154                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     155                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl                                                    156                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl                                                    157                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl                                                    158                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                159                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl                                                160                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                161                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                162                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             163                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             164                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             165                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             166                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             167                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             168                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 169                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     170                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     171                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     172                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 173                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  174                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  175                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-propylphenyl                                                  176                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethoxyphenyl                                            177                                                                               SC(S)NR'R                                                                             CH.sub. 3                                                                         2,4,6-trimethoxyphenyl                                            178                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethoxyphenyl                                            179                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethoxyphenyl                                                    180                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethoxyphenyl                                                    181                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethoxyphenyl                                                    182                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropoxyphenyl                                                183                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropoxyphenyl                                                184                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-isopropoxyphenyl                                                185                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butoxyphenyl                                              186                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butoxyphenyl                                              187                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethoxyphenyl                                          188                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethoxyphenyl                                          189                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethoxyphenyl                                          190                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(1',1',2',2'-tetra-fluoro)-ethoxyphenyl                         191                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',1',2',2'-tetra-fluoro)-ethoxyphenyl                         192                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloromethylphenyl                                              193                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloromethylphenyl                                              194                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-chloromethylphenyl                                              195                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethylphenyl                                           196                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethylphenyl                                           197                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethylphenyl                                           198                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(methoxyiminomethyl)-phenyl                                     199                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(methoxyiminomethyl)-phenyl                                     200                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(methoxyiminomethyl)-phenyl                                     201                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(ethoxyiminomethyl)-phenyl                                      202                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(ethoxyiminomethyl)-phenyl                                      203                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(ethoxyiminomethyl)-phenyl                                      204                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinoethyl-phenyl                                205                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinomethyl-phenyl                               206                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximinomethyl-phenyl                           207                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximinoethyl-phenyl                            208                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenylphenyl                                                    209                                                                               SC(S)NR'R                                                                             CH.sub. 3                                                                         3-phenylphenyl                                                    210                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenylphenyl                                                    211                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenoxyphenyl                                                   212                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-phenoxyphenyl                                                   213                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenoxyphenyl                                                   214                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzyloxyphenyl                                                 215                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-benzyloxyphenyl                                                 216                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-benzyloxyphenyl                                                 217                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(imidazol-1'-yl)phenyl                                          218                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperazin-1'-yl)phenyl                                         219                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(morpholin-1'-yl)phenyl                                         220                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperidin-1'-yl)phenyl                                         221                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(pyridyl-2'-oxy)phenyl                                          222                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyclopropylphenyl                                               223                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclopropylphenyl                                               224                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclopropylphenyl                                               225                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclohexylphenyl                                                226                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclohexylphenyl                                                227                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-oxiranylphenyl                                                  228                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',3'-dioxan-2'-yl)-phenyl                                     229                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(tetrahydropyran-2-yl-oxy)-phenyl                               230                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-naphthyl                                                        231                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-naphthyl                                                        232                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          benzyl              4.50 (CH.sub.2) amide rotamers                233                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylbenzyl                                                    234                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylbenzyl                                                    235                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylbenzyl                                                    236                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylbenzyl 1.31(9H), 4.50(CH.sub.2) amide rotamers       237                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorobenzyl                                                    238                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chlorobenzyl                                                    239                                                                               SC(S)NR'R                                                                             CH.sub. 3                                                                         4-chlorobenzyl                                                    240                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridyl                                                         241                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridyl                                                         242                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridyl                                                         243                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-pyrimidinyl                                                   244                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,5-pyrimidinyl                                                   245                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-thienyl                                                         246                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-thienyl                                                         247                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-furyl                                                           248                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-furyl                                                           249                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-pyrrolyl                                                        250                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-imidazolyl                                                      251                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,2,4-triazolyl                                                   252                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,3,4-triazolyl                                                   253                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-thiazolyl                                                       254                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzothiazolyl                                                  255                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridylmethyl                                                   256                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridylmethyl                                                   257                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridylmethyl                                                   258                                                                               SC(S)NR'R                                                                             Et phenyl              1.26(9H), 3.57, 3.72(3H), 4.24(2 ×                                       2H)                                           259                                                                               SC(S)NR'R                                                                             Et 2-methylphenyl                                                    260                                                                               SC(S)NR'R                                                                             Et 2-chlorophenyl                                                    261                                                                               SC(S)NR'R                                                                             Et 4-methylphenyl      107-112° C.                            262                                                                               SC(S)NR'R                                                                             Et 2-naphtyl                                                         263                                                                               SC(S)SR                                                                               -- CH.sub.3                                                          264                                                                               SC(S)SR                                                                               -- CH.sub.2 -phenyl                                                  265                                                                               SC(S)SR                                                                               -- phenyl                                                            266                                                                               SC(S)SR                                                                               -- A*                  3.67, 3.77(3H), 4.55(2H), 7.39(1H)            267                                                                               SC(S)OR                                                                               -- CH.sub.3                                                          268                                                                               SC(S)OR                                                                               -- phenyl                                                            269                                                                               SC(S)OR                                                                               -- 2-CH.sub.3 -phenyl                                                270                                                                               SC(S)OR                                                                               -- 3-CH.sub.3 -phenyl  2.38, 3.71, 3.84(3H), 4.39(2H)                271                                                                               SC(S)OR                                                                               -- 4-CH.sub.3 -phenyl                                                272                                                                               SC(S)OR                                                                               -- 2-Cl-phenyl                                                       273                                                                               SC(S)OR                                                                               -- 3-Cl-phenyl                                                       274                                                                               SC(S)OR                                                                               -- 4-Cl-phenyl                                                       275                                                                               SC(S)OR                                                                               -- CH.sub.2 -phenyl    1707, 1633, 1256, 1197, 1126, 1054            276                                                                               SC(S)OR                                                                               -- CH.sub.2(2-Me)-phenyl                                                                              2.35, 3.69, 3.81(3H), 4.32, 5.63(2H),                                          7.58(1H)                                      277                                                                               SC(S)OR                                                                               -- CH.sub.2(3-Me)-phenyl                                             278                                                                               SC(S)OR                                                                               -- CH.sub.2(4-Me)-phenyl                                             279                                                                               SC(S)OR                                                                               -- CH.sub.2(2-Cl)-phenyl                                                                              1746, 1462, 1255, 1127, 1060                  280                                                                               SC(S)OR                                                                               -- CH.sub.2(3-Cl)phenyl                                              281                                                                               SC(S)OR                                                                               -- CH.sub.2(4-Cl)phenyl                                              282                                                                               OC(O)OR                                                                               -- CH.sub.3                                                          283                                                                               OC(O)OR                                                                               -- tert.-butyl                                                       284                                                                               OC(O)OR                                                                               -- CH.sub.2 -phenyl                                                  285                                                                               OC(O)OR                                                                               -- phenyl                                                            286                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-Me, 4-F-phenyl    2.25; 3.57; 3.72; 3.75(4 × 3H);                                          4.35(2H); 7.00-7.41(7H); 7.51(1H)             287                                                                               SC(S)NR'R                                                                             H  2-phenyl-eth-2-yl   7.58(1H) amide rotamers                       288                                                                               SC(S)NR'R                                                                             Me 4-tert-butoxybenzyl 98-102° C.                             289                                                                               SC(S)NR'R                                                                             Et 3,4-(OCH.sub.2 O)phenyl                                                                            130-134° C.                            290                                                                               SC(S)OR                                                                               -- ethyl               1708, 1633, 1257, 1126, 1048                  291                                                                               SC(S)OR                                                                               -- isopropyl           1707, 1632, 1250, 1226, 1224, 1089,                                            1037                                          292                                                                               SC(S)OR                                                                               -- 4-methoxybenzyl     3.70, 3.80, 3.83(3H), 4.57(2H),                                                7.58(1H)                                      293                                                                               SC(S)NR'R                                                                             Me CH.sub.2(3-pyridyl) 1705, 1633, 1480, 1432, 1384, 1258,                                            1198, 1125, 989                               __________________________________________________________________________      ##STR18##                                                                      .sup.a) IR (cm.sup.-1); .sup.1 HNMR (CDCl.sub.3 /TMS); m. p.             

                                      TABLE 2                                      __________________________________________________________________________      ##STR19##                                                                     No.                                                                               D      R' R               phys. data.sup.a)                                 __________________________________________________________________________     1  SC(S)NR'R                                                                             CH.sub.3                                                                          methyl                                                            2  SC(S)NR'R                                                                             CH.sub.3                                                                          ethyl                                                             3  SC(S)NR'R                                                                             CH.sub.3                                                                          n-propyl                                                          4  SC(S)NR'R                                                                             CH.sub.3                                                                          tert.-butyl                                                       5  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclopropyl                                                       6  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclohexyl      2934, 1727, 1473, 1439, 1393, 1319,                                            1216, 1087, 1067, 1017                            7  SC(S)NR'R                                                                             CH.sub.3                                                                          methoxymethyl                                                     8  SC(S)NR'R                                                                             CH.sub.3                                                                          phenoxymethyl                                                     9  SC(S)NR'R                                                                             CH.sub.3                                                                          methylthiomethyl                                                  10 SC(S)NR'R                                                                             CH.sub.3                                                                          phenyl          3.75; 3.76; 3.95 (3 × 3H); 4.32(2H);                                     7.08-7.51 (9H);                                   11 SC(S)NR'R                                                                             CH.sub.3                                                                          2-fluorophenyl                                                    12 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluorophenyl  3.73; 3.80; 3.99 (3 × 3H); 4.33 (2H);                                    6.95-7.50 (8H)                                    13 SC(S)NR'R                                                                             CH.sub.3                                                                          4-fluorophenyl  3.72; 3.77; 3.97 (3 × 3H); 4.32 (2H);                                    7.07-7.48 (8H)                                    14 SC(S)NR'R                                                                             CH.sub.3                                                                          pentafluorophenyl                                                 15 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorophenyl                                                    16 SC(S)NR' R                                                                            CH.sub.3                                                                          3-chlorophenyl  3.72; 3.80; 3.97 (3 × 3H); 4.34 (2H);                                    7.10-7.49 (8H)                                    17 SC(S)NR'R                                                                             CH.sub.3                                                                          4-chlorophenyl  2.91, 3.72, 4.05 (3H), 4.30 (2H),                                              6.57-7.40 ppm (8H)                                18 SC(S)NR'R                                                                             CH.sub.3                                                                          pentachlorophenyl                                                 19 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3-dichlorophenyl                                                20 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dichlorophenyl                                                21 SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dichlorophenyl                                                22 SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dichlorophenyl                                                23 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dichlorophenyl                                                24 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dichlorophenyl                                                25 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trichlorophenyl                                             26 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trichlorophenyl                                             27 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trichlorophenyl                                             28 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             29 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichlorophenyl                                             30 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trichlorophenyl                                             31 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         32 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         33 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     34 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     35 SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     36 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 37 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            38 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           39 SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      40 SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      41 SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      42 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           43 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           44 SC(S)NR'R                                                                             CH.sub. 3                                                                         2-chloro-6-fluorophenyl                                           45 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            46 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            47 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-fluorophenyl                                            48 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            49 SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-fluorophenyl                                           50 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           51 SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     52 SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     53 SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     54 SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     55 SC(S)NR'R                                                                             CH.sub.3                                                                          3-nitrophenyl                                                     56 SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     57 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl  2.17; 3.69; 3.76; 3.95; (4 × 3H);                                        4.33 (2H); 7.06-7.50 (8H)                         58 SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl  2.36; 3.74; 3.77; 3.96; (4 × 3H);                                        4.32 (2H); 6.98-7.48 (8H)                         59 SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl  2.35; 3.72; 3.77; 3.97; (4 × 3H);                                        4.30 (2H); 7.07-7.47 (8H)                         60 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                61 SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl                                                62 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                63 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                64 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             65 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             66 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             67 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             68 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             69 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethylphenyl                                             70 SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 71 SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     72 SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     73 SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     74 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 75 SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  76 SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  77 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-propylphenyl                                                  78 SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropylphenyl                                                 79 SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropylphenyl                                                 80 SC(S)NR'R                                                                             CH.sub.3                                                                          4-isopropylphenyl                                                 81 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-diisopropylphenyl                                             82 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diisopropylphenyl                                             83 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-butyphenyl                                                    84 SC(S)NR'R                                                                             CH.sub.3                                                                          4-sec.-butylphenyl                                                85 SC(S)NR'R                                                                             CH.sub.3                                                                          4-isobutylphenyl                                                  86 SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylphenyl                                               87 SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butylphenyl                                               88 SC(S)NR'R                                                                             CH.sub.3                                                                          2-tert.-butylphenyl                                               89 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-di-tert.-butylphenyl                                          90 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-di-tert.-butylphenyl                                          91 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-hexylphenyl                                                   92 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-dodecylphenyl                                                 93 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-tert.-butylphenyl                                      94 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-tert.-butylphenyl                                      95 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropylphenyl                                        96 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-cyclohexylphenyl                                       97 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenylphenyl                                           98 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzylphenyl                                           99 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenoxyphenyl                                          100                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzyloxyphenyl                                        101                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-chlorophenyl                                           102                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-chlorophenyl                                           103                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-chlorophenyl                                           104                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-chlorophenyl                                           105                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-fluorophenyl                                           106                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-bromophenyl                                            107                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-bromophenyl                                            108                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-methoxyphenyl                                          109                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoxyphenyl                                          110                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-methoxyphenyl                                          111                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-methoxyphenyl                                          112                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropoxyphenyl                                       113                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-2,5-dimethoxyphenyl                                      114                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methoxyphenyl                                                   115                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methoxyphenyl                                                   116                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methoxyphenyl                                                   117                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3-dimethoxyphenyl                                               118                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethoxyphenyl                                               119                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dimethoxyphenyl                                               120                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethoxyphenyl                                               121                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethoxyphenyl                                               122                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethoxyphenyl                                               123                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,6-dimethoxyphenyl                                               124                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethoxyphenyl                                            125                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethoxyphenyl                                            126                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethoxyphenyl                                            127                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             128                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichloroyphenyl                                            129                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         130                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         131                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     132                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     133                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     134                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 135                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            136                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           137                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      138                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      139                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      140                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           141                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           142                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-6-fluorophenyl                                           143                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            144                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            145                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-fluorophenyl                                            146                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-chlorophenyl                                            147                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-fluorophenyl                                           148                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           149                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     150                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     151                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     152                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     153                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-nitrophenyl                                                     154                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     155                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl                                                    156                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl                                                    157                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl                                                    158                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                159                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl                                                160                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                161                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                162                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             163                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             164                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             165                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             166                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             167                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             168                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 169                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     170                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     171                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     172                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 173                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  174                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  175                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-propylphenyl                                                  176                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethoxyphenyl                                            177                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethoxyphenyl                                            178                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethoxyphenyl                                            179                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethoxyphenyl                                                    180                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethoxyphenyl                                                    181                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethoxyphenyl                                                    182                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropoxyphenyl                                                183                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropoxyphenyl                                                184                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-isopropoxyphenyl                                                185                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butoxyphenyl                                              186                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butoxyphenyl                                              187                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethoxyphenyl                                          188                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethoxyphenyl                                          189                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethoxyphenyl                                          190                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(1',1',2',2'-tetra-                                                          fluoro)-ethoxyphenyl                                              191                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',1',2',2'-tetra-                                                          fluoro)-ethoxyphenyl                                              192                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloromethylphenyl                                              193                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloromethylphenyl                                              194                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-chloromethylphenyl                                              195                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethylphenyl                                           196                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethylphenyl                                           197                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethylphenyl                                           198                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(methoxyiminomethyl)-phenyl                                     199                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(methoxyiminomethyl)-phenyl                                     200                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(methoxyiminomethyl)-phenyl                                     201                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(ethoxyiminomethyl)-phenyl                                      202                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(ethoxyiminomethyl)-phenyl                                      203                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(ethoxyiminomethyl)-phenyl                                      204                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinoethyl-                                                   phenyl                                                            205                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinomethyl-                                                  phenyl                                                            206                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximino-                                                    methyl-phenyl                                                     207                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximino-                                                    ethyl-phenyl                                                      208                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenylphenyl                                                    209                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-phenylphenyl                                                    210                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenylphenyl                                                    211                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenoxyphenyl                                                   212                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-phenoxyphenyl                                                   213                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenoxyphenyl                                                   214                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzyloxyphenyl                                                 215                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-benzyloxyphenyl                                                 216                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-benzyloxyphenyl                                                 217                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(imidazol-1'-yl)phenyl                                          218                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperazin-1'-yl)phenyl                                         219                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(morpholin-1'-yl)phenyl                                         220                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperidin-1'-yl)phenyl                                         221                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(pyridyl-2'-oxy)phenyl                                          222                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyclopropylphenyl                                               223                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclopropylphenyl                                               224                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclopropylphenyl                                               225                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclohexylphenyl                                                226                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclohexylphenyl                                                227                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-oxiranylphenyl                                                  228                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',3'-dioxan-2'-yl)-phenyl                                     229                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(tetrahydropyran-2-yl-                                                       oxy)-phenyl                                                       230                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-naphthyl                                                        231                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-naphthyl                                                        232                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          benzyl          84-90° C.                                  233                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylbenzyl                                                    234                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylbenzyl                                                    235                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylbenzyl                                                    236                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylbenzyl                                                                            1.31 (9H), 4.50 (2H) amide rotamers               237                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorobenzyl                                                    238                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chlorobenzyl                                                    239                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-chlorobenzyl                                                    240                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridyl                                                         241                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridyl                                                         242                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridyl                                                         243                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-pyrimidinyl                                                   244                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,5-pyrimidinyl                                                   245                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-thienyl                                                         246                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-thienyl                                                         247                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-furyl                                                           248                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-furyl                                                           249                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-pyrrolyl                                                        250                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-imidazolyl                                                      251                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,2,4-triazolyl                                                   252                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,3,4-triazolyl                                                   253                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-thiazolyl                                                       254                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzothiazolyl                                                  255                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridylmethyl                                                   256                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridylmethyl                                                   257                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridylmethyl                                                   258                                                                               SC(S)NR'R                                                                             Et phenyl          1.24 (3H), 3.76, 3.94 (3H), 4.03 (2 ×                                    CH.sub. 2)                                        259                                                                               SC(S)NR'R                                                                             Et 2-methylphenyl                                                    260                                                                               SC(S)NR'R                                                                             Et 2-chlorophenyl                                                    261                                                                               SC(S)NR'R                                                                             Et 4-methylphenyl  1633, 1523, 1508, 1444, 1399, 1305,                                            1272, 1103, 1038                                  262                                                                               SC(S)NR'R                                                                             Et 2-naphtyl       110-114° C.                                263                                                                               SC(S)SR                                                                               -- CH.sub.3                                                          264                                                                               SC(S)SR                                                                               -- CH.sub.2 -phenyl                                                  265                                                                               SC(S)SR                                                                               -- phenyl                                                            266                                                                               SC(S)SR                                                                               -- A*              114-115° C.                                267                                                                               SC(S)OR                                                                               -- CH.sub.3        3.85, 4.04, 4.14 (3H); 4.25 (2H)                  268                                                                               SC(S)OR                                                                               -- phenyl                                                            269                                                                               SC(S)OR                                                                               -- 2-CH.sub.3 -phenyl                                                270                                                                               SC(S)OR                                                                               -- 3-CH.sub.3 -phenyl                                                271                                                                               SC(S)OR                                                                               -- 4-CH.sub.3 -phenyl                                                272                                                                               SC(S)OR                                                                               -- 2-Cl-phenyl                                                       273                                                                               SC(S)OR                                                                               -- 3-Cl-phenyl                                                       274                                                                               SC(S)OR                                                                               -- 4-Cl-phenyl                                                       275                                                                               SC(S)OR                                                                               -- CH.sub.2 -phenyl                                                  276                                                                               SC(S)OR                                                                               -- CH.sub.2 -(2-Me)-phenyl                                                                        1727, 1436, 1218, 1066, 1017                      277                                                                               SC(S)OR                                                                               -- CH.sub.2 -(3-Me)-phenyl                                                                        1727, 1437, 1218, 1066, 1018                      278                                                                               SC(S)OR                                                                               -- CH.sub.2 -(4-Me)-phenyl                                           279                                                                               SC(S)OR                                                                               -- CH.sub.2 -(2-Cl)-phenyl                                                                        1727, 1442, 1221, 1065, 1017                      280                                                                               SC(S)OR                                                                               -- CH.sub.2 -(3-Cl)phenyl                                                                         3.86, 4.04 (3H), 4.28, 5.58 (2H)                  281                                                                               SC(S)OR                                                                               -- CH.sub.2 -(4-Cl)phenyl                                            282                                                                               OC(O)OR                                                                               -- CH.sub.3                                                          283                                                                               OC(O)OR                                                                               -- tert.-butyl                                                       284                                                                               OC(O)OR                                                                               -- CH.sub.2 -phenyl                                                  285                                                                               OC(O)OR                                                                               -- phenyl                                                            286                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-Me, 4-F-phenyl                                                                               2.27; 3.71; 3.78; 3.97 (4 × 3H);                                         4.32 (2H); 7.00-7.49 (7H)                         287                                                                               SC(S)NR'R                                                                             H  2-phenyl-eth-2-yl                                                                              102-103° C.                                288                                                                               SC(S)NR'R                                                                             Me 4-tert-butoxybenzyl                                                                            2975, 1726, 1656, 1482, 1387, 1236,                                            1216, 1161, 1066, 1017                            289                                                                               SC(S)NR'R                                                                             Et 3,4-(-OCH.sub.2 O-)phenyl                                                                      108-113° C.                                290                                                                               SC(S)OR                                                                               -- ethyl           1727, 1437, 1321, 1218, 1066, 1047, 1017          291                                                                               SC(S)OR                                                                               -- isopropyl       1726, 1436, 1218, 1090, 1066, 1040, 101           292                                                                               SC(S)OR                                                                               -- benzyl          3.87, 4.05 (3H), 4.27, 5.63                       __________________________________________________________________________                                  (2H)                                               ##STR20##                                                                      .sup.a) IR (cm.sup.-1); .sup.1 HNMR (CDCl.sub.3 /TMS); m. p.             

                  TABLE 3                                                          ______________________________________                                          ##STR21##                                                                     No.  D          R'     R             phys. data.sup.a)                         ______________________________________                                         1    SC(S)NR'R  CH.sub.3                                                                              methyl                                                  2    SC(S)NR'R  CH.sub.3                                                                              ethyl                                                   3    SC(S)NR'R  CH.sub.3                                                                              n-propyl                                                4    SC(S)NR'R  CH.sub.3                                                                              tert.-butyl                                             5    SC(S)NR'R  CH.sub.3                                                                              cyclopropyl                                             6    SC(S)NR'R  CH.sub.3                                                                              cyclohexyl                                              7    SC(S)NR'R  CH.sub.3                                                                              methoxymethyl                                           8    SC(S)NR'R  CH.sub.3                                                                              phenoxymethyl                                           9    SC(S)NR'R  CH.sub.3                                                                              methylthiomethyl                                        10   SC(S)NR'R  CH.sub.3                                                                              phenyl                                                  11   SC(S)NR'R  CH.sub.3                                                                              2-fluorophenyl                                          12   SC(S)NR'R  CH.sub.3                                                                              3-fluorophenyl                                          13   SC(S)NR'R  CH.sub.3                                                                              4-fluorophenyl                                          14   SC(S)NR'R  CH.sub.3                                                                              pentafluorophenyl                                       15   SC(S)NR'R  CH.sub.3                                                                              2-chlorophenyl                                          16   SC(S)NR'R  CH.sub.3                                                                              3-chlorophenyl                                          17   SC(S)NR'R  CH.sub.3                                                                              4-chlorophenyl                                          18   SC(S)NR'R  CH.sub.3                                                                              pentachlorophenyl                                       19   SC(S)NR'R  CH.sub.3                                                                              2,3-dichlorophenyl                                      20   SC(S)NR'R  CH.sub.3                                                                              2,,4-dichlorophenyl                                     21   SC(S)NR'R  CH.sub.3                                                                              2,5-dichlorophenyl                                      22   SC(S)NR'R  CH.sub.3                                                                              2,6-dichlorophenyl                                      23   SC(S)NR'R  CH.sub.3                                                                              3,4-dichlorophenyl                                      24   SC(S)NR'R  CH.sub.3                                                                              3,5-dichlorophenyl                                      25   SC(S)NR'R  CH.sub.3                                                                              2,3,4-trichlorophenyl                                   26   SC(S)NR'R  CH.sub.3                                                                              2,3,5-trichlorophenyl                                   27   SC(S)NR'R  CH.sub.3                                                                              2,3,6-trichlorophenyl                                   28   SC(S)NR'R  CH.sub.3                                                                              2,4,5-trichlorophenyl                                   29   SC(S)NR'R  CH.sub.3                                                                              2,4,6-trichlorophenyl                                   30   SC(S)NR'R  CH.sub.3                                                                              3,4,5-trichlorophenyl                                   31   SC(S)NR'R  CH.sub.3                                                                              2,3,4,6-tetrachlorophenyl                               32   SC(S)NR'R  CH.sub.3                                                                              2,3,5,6-tetrachlorophenyl                               33   SC(S)NR'R  CH.sub.3                                                                              2-bromophenyl                                           34   SC(S)NR'R  CH.sub.3                                                                              3-bromophenyl                                           35   SC(S)NR'R  CH.sub.3                                                                              4-bromophenyl                                           36   SC(S)NR'R  CH.sub.3                                                                              2,4-dibromophenyl                                       37   SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-fluorophenyl                                  38   SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-                                                                     methoxyphenyl                                           39   SC(S)NR'R  CH.sub.3                                                                              2-iodophenyl                                            40   SC(S)NR'R  CH.sub.3                                                                              3-iodophenyl                                            41   SC(S)NR'R  CH.sub.3                                                                              4-iodophenyl                                            42   SC(S)NR'R  CH.sub.3                                                                              2-chloro-4-fluorophenyl                                 43   SC(S)NR'R  CH.sub.3                                                                              2-chloro-5-fluorophenyl                                 44   SC(S)NR'R  CH.sub.3                                                                              2-chloro-6-fluorophenyl                                 45   SC(S)NR'R  CH.sub.3                                                                              2-chloro-4-bromophenyl                                  46   SC(S)NR'R  CH.sub.3                                                                              2-bromo-4-chlorophenyl                                  47   SC(S)NR'R  CH.sub.3                                                                              2-bromo-4-fluorophenyl                                  48   SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-fluorophenyl                                  49   SC(S)NR'R  CH.sub.3                                                                              3-chloro-4-fluorophenyl                                 50   SC(S)NR'R  CH.sub.3                                                                              3-fluoro-4-chlorophenyl                                 51   SC(S)NR'R  CH.sub.3                                                                              2-cyanophenyl                                           52   SC(S)NR'R  CH.sub.3                                                                              3-cyanophenyl                                           53   SC(S)NR'R  CH.sub.3                                                                              4-cyanophenyl                                           54   SC(S)NR'R  CH.sub.3                                                                              2-nitrophenyl                                           55   SC(S)NR'R  CH.sub.3                                                                              3-nitrophenyl                                           56   SC(S)NR'R  CH.sub.3                                                                              4-nitrophenyl                                           57   SC(S)NR'R  CH.sub.3                                                                              2-methylphenyl                                          58   SC(S)NR'R  CH.sub.3                                                                              3-methylphenyl                                          59   SC(S)NR'R  CH.sub.3                                                                              4-methylphenyl                                          60   SC(S)NR'R  CH.sub.3                                                                              2,4-dimethylphenyl                                      61   SC(S)NR'R  CH.sub.3                                                                              2,6-dimethylphenyl                                      62   SC(S)NR'R  CH.sub.3                                                                              3,4-dimethylphenyl                                      63   SC(S)NR'R  CH.sub.3                                                                              3,5-dimethylphenyl                                      64   SC(S)NR'R  CH.sub.3                                                                              2,3,4-trimethylphenyl                                   65   SC(S)NR'R  CH.sub.3                                                                              2,3,5-trimethylphenyl                                   66   SC(S)NR'R  CH.sub.3                                                                              2,3,6-trimethylphenyl                                   67   SC(S)NR'R  CH.sub.3                                                                              2,4,5-trimethylphenyl                                   68   SC(S)NR'R  CH.sub.3                                                                              2,4,6-trimethylphenyl                                   69   SC(S)NR'R  CH.sub.3                                                                              3,4,5-trimethylphenyl                                   70   SC(S)NR'R  CH.sub.3                                                                              pentamethylphenyl                                       71   SC(S)NR'R  CH.sub.3                                                                              2-ethylphenyl                                           72   SC(S)NR'R  CH.sub.3                                                                              3-ethylphenyl                                           73   SC(S)NR'R  CH.sub.3                                                                              4-ethylphenyl                                           74   SC(S)NR'R  CH.sub.3                                                                              3,5-diethylphenyl                                       75   SC(S)NR'R  CH.sub.3                                                                              2-n-propylphenyl                                        76   SC(S)NR'R  CH.sub.3                                                                              3-n-propylphenyl                                        77   SC(S)NR'R  CH.sub.3                                                                              4-n-propylphenyl                                        78   SC(S)NR'R  CH.sub.3                                                                              2-isopropylphenyl                                       79   SC(S)NR'R  CH.sub.3                                                                              3-isopropylphenyl                                       80   SC(S)NR'R  CH.sub.3                                                                              4-isopropylphenyl                                       81   SC(S)NR'R  CH.sub.3                                                                              2,4-diisopropylphenyl                                   82   SC(S)NR'R  CH.sub.3                                                                              3,5-diisopropylphenyl                                   83   SC(S)NR'R  CH.sub.3                                                                              4-n-butyphenyl                                          84   SC(S)NR'R  CH.sub.3                                                                              4-sec.-butylphenyl                                      85   SC(S)NR'R  CH.sub.3                                                                              4-iso-butylphenyl                                       86   SC(S)NR'R  CH.sub.3                                                                              4-tert.-butylphenyl                                     87   SC(S)NR'R  CH.sub.3                                                                              3-tert.-butylphenyl                                     88   SC(S)NR'R  CH.sub.3                                                                              2-tert.-butylphenyl                                     89   SC(S)NR'R  CH.sub.3                                                                              2,4-di-tert.-butylphenyl                                90   SC(S)NR'R  CH.sub.3                                                                              3,5-di-tert.-butylphenyl                                91   SC(S)NR'R  CH.sub.3                                                                              4-n-hexylphenyl                                         92   SC(S)NR'R  CH.sub.3                                                                              4-n-dodecylphenyl                                       93   SC(S)NR'R  CH.sub.3                                                                              2-methyl-                                                                      4-tert.-butylphenyl                                     94   SC(S)NR'R  CH.sub.3                                                                              2-methyl-6-                                                                    tert.-butylphenyl                                       95   SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    isopropylphenyl                                         96   SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    cyclohexylphenyl                                        97   SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-phenylphenyl                                 98   SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-benzylphenyl                                 99   SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    phenoxyphenyl                                           100  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    benzyloxyphenyl                                         101  SC(S)NR'R  CH.sub.3                                                                              2-methyl-3-chlorophenyl                                 102  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-chlorophenyl                                 103  SC(S)NR'R  CH.sub.3                                                                              2-methyl-5-chlorophenyl                                 104  SC(S)NR'R  CH.sub.3                                                                              2-methyl-6-chlorophenyl                                 105  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-fluorophenyl                                 106  SC(S)NR'R  CH.sub.3                                                                              2-methyl-3-bromophenyl                                  107  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-bromophenyl                                  108  SC(S)NR'R  CH.sub.3                                                                              2-methyl-3-                                                                    methoxyphenyl                                           109  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    methoxyphenyl                                           110  SC(S)NR'R  CH.sub.3                                                                              2-methyl-5-                                                                    methoxyphenyl                                           111  SC(S)NR'R  CH.sub.3                                                                              2-methyl-6-                                                                    methoxyphenyl                                           112  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    isopropoxyphenyl                                        113  SC(S)NR'R  CH.sub.3                                                                              2-methyl-2,5-                                                                  dimethoxyphenyl                                         114  SC(S)NR'R  CH.sub.3                                                                              2-methoxyphenyl                                         115  SC(S)NR'R  CH.sub.3                                                                              3-methoxyphenyl                                         116  SC(S)NR'R  CH.sub.3                                                                              4-methoxyphenyl                                         117  SC(S)NR'R  CH.sub.3                                                                              2,3-dimethoxyphenyl                                     118  SC(S)NR'R  CH.sub.3                                                                              2,4-dimethoxyphenyl                                     119  SC(S)NR'R  CH.sub.3                                                                              2,5-dimethoxyphenyl                                     120  SC(S)NR'R  CH.sub.3                                                                              2,6-dimethoxyphenyl                                     121  SC(S)NR'R  CH.sub.3                                                                              3,4-dimethoxyphenyl                                     122  SC(S)NR'R  CH.sub.3                                                                              3,5-dimethoxyphenyl                                     123  SC(S)NR'R  CH.sub.3                                                                              3,6-dimethoxyphenyl                                     124  SC(S)NR'R  CH.sub.3                                                                              2,3,4-trimethoxyphenyl                                  125  SC(S)NR'R  CH.sub.3                                                                              2,3,5-trimethoxyphenyl                                  126  SC(S)NR'R  CH.sub.3                                                                              2,3,6-trimethoxyphenyl                                  127  SC(S)NR'R  CH.sub.3                                                                              2,4,5-trichlorophenyl                                   128  SC(S)NR'R  CH.sub.3                                                                              2,4,6-trichloroyphenyl                                  129  SC(S)NR'R  CH.sub.3                                                                              2,3,4,6-tetrachlorophenyl                               130  SC(S)NR'R  CH.sub.3                                                                              2,3,5,6-tetrachlorophenyl                               131  SC(S)NR'R  CH.sub.3                                                                              2-bromophenyl                                           132  SC(S)NR'R  CH.sub.3                                                                              3-bromophenyl                                           133  SC(S)NR'R  CH.sub.3                                                                              4-bromophenyl                                           134  SC(S)NR'R  CH.sub.3                                                                              2,4-dibromophenyl                                       135  SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-fluorophenyl                                  136  SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-                                                                     methoxyphenyl                                           137  SC(S)NR'R  CH.sub.3                                                                              2-iodophenyl                                            138  SC(S)NR'R  CH.sub.3                                                                              3-iodophenyl                                            139  SC(S)NR'R  CH.sub.3                                                                              4-iodophenyl                                            140  SC(S)NR'R  CH.sub.3                                                                              2-chloro-4-fluorophenyl                                 141  SC(S)NR'R  CH.sub.3                                                                              2-chloro-5-fluorophenyl                                 142  SC(S)NR'R  CH.sub.3                                                                              2-chloro-6-fluorophenyl                                 143  SC(S)NR'R  CH.sub.3                                                                              2-chloro-4-bromophenyl                                  144  SC(S)NR'R  CH.sub.3                                                                              2-bromo-4-chlorophenyl                                  145  SC(S)NR'R  CH.sub.3                                                                              2-bromo-4-fluorophenyl                                  146  SC(S)NR'R  CH.sub.3                                                                              3-bromo-4-chlorophenyl                                  147  SC(S)NR'R  CH.sub.3                                                                              3-chloro-4-fluorophenyl                                 148  SC(S)NR'R  CH.sub.3                                                                              3-fluoro-4-chlorophenyl                                 149  SC(S)NR'R  CH.sub.3                                                                              2-cyanophenyl                                           150  SC(S)NR'R  CH.sub.3                                                                              3-cyanophenyl                                           151  SC(S)NR'R  CH.sub.3                                                                              4-cyanophenyl                                           152  SC(S)NR'R  CH.sub.3                                                                              2-nitrophenyl                                           153  SC(S)NR'R  CH.sub.3                                                                              3-nitrophenyl                                           154  SC(S)NR'R  CH.sub.3                                                                              4-nitrophenyl                                           155  SC(S)NR'R  CH.sub.3                                                                              2-methylphenyl                                          156  SC(S)NR'R  CH.sub.3                                                                              3-methylphenyl                                          157  SC(S)NR'R  CH.sub.3                                                                              4-methylphenyl                                          158  SC(S)NR'R  CH.sub.3                                                                              2,4-dimethylphenyl                                      159  SC(S)NR'R  CH.sub.3                                                                              2,6-dimethylphenyl                                      160  SC(S)NR'R  CH.sub.3                                                                              3,4-dimethylphenyl                                      161  SC(S)NR'R  CH.sub.3                                                                              3,5-dimethylphenyl                                      162  SC(S)NR'R  CH.sub.3                                                                              2,3,4-trimethylphenyl                                   163  SC(S)NR'R  CH.sub.3                                                                              2,3,5-trimethylphenyl                                   164  SC(S)NR'R  CH.sub.3                                                                              2,3,6-trimethylphenyl                                   165  SC(S)NR'R  CH.sub.3                                                                              2,4,5-trimethylphenyl                                   166  SC(S)NR'R  CH.sub.3                                                                              2,4,6-trimethylphenyl                                   167  SC(S)NR'R  CH.sub.3                                                                              2,4,5-trimethylphenyl                                   168  SC(S)NR'R  CH.sub.3                                                                              pentamethylphenyl                                       169  SC(S)NR'R  CH.sub.3                                                                              2-ethylphenyl                                           170  SC(S)NR'R  CH.sub.3                                                                              3-ethylphenyl                                           171  SC(S)NR'R  CH.sub.3                                                                              4-ethylphenyl                                           172  SC(S)NR'R  CH.sub.3                                                                              3,5-diethylphenyl                                       173  SC(S)NR'R  CH.sub.3                                                                              2-n-propylphenyl                                        174  SC(S)NR'R  CH.sub.3                                                                              3-n-propylphenyl                                        175  SC(S)NR'R  CH.sub.3                                                                              4-n-propylphenyl                                        176  SC(S)NR'R  CH.sub.3                                                                              2,4,5-trimethoxyphenyl                                  177  SC(S)NR'R  CH.sub.3                                                                              2,4,6-trimethoxyphenyl                                  178  SC(S)NR'R  CH.sub.3                                                                              3,4,5-trimethoxyphenyl                                  179  SC(S)NR'R  CH.sub.3                                                                              2-ethoxyphenyl                                          180  SC(S)NR'R  CH.sub.3                                                                              3-ethoxyphenyl                                          181  SC(S)NR'R  CH.sub.3                                                                              4-ethoxyphenyl                                          182  SC(S)NR'R  CH.sub.3                                                                              2-isopropoxyphenyl                                      183  SC(S)NR'R  CH.sub.3                                                                              3-isopropoxyphenyl                                      184  SC(S)NR'R  CH.sub.3                                                                              4-isopropoxyphenyl                                      185  SC(S)NR'R  CH.sub.3                                                                              3-tert.-butoxyphenyl                                    186  SC(S)NR'R  CH.sub.3                                                                              4-tert.-butoxyphenyl                                    187  SC(S)NR'R  CH.sub.3                                                                              2-trifluoro-                                                                   methoxyphenyl                                           188  SC(S)NR'R  CH.sub.3                                                                              3-trifluoro-                                                                   methoxyphenyl                                           189  SC(S)NR'R  CH.sub.3                                                                              4-trifluoro-                                                                   methoxyphenyl                                           190  SC(S)NR'R  CH.sub.3                                                                              3-(1',1',2',2'-                                                                tetrafluoro)-                                                                  ethoxyphenyl                                            191  SC(S)NR'R  CH.sub.3                                                                              4-(1',1',2',2'-                                                                tetrafluoro)-                                                                  ethoxyphenyl                                            192  SC(S)NR'R  CH.sub.3                                                                              2-chloromethylphenyl                                    193  SC(S)NR'R  CH.sub.3                                                                              3-chloromethylphenyl                                    194  SC(S)NR'R  CH.sub.3                                                                              4-chloromethylphenyl                                    195  SC(S)NR'R  CH.sub.3                                                                              2-trifluoromethylphenyl                                 196  SC(S)NR'R  CH.sub.3                                                                              3-trifluoromethylphenyl                                 197  SC(S)NR'R  CH.sub.3                                                                              4-trifluoromethylphenyl                                 198  SC(S)NR'R  CH.sub.3                                                                              2-(methoxyiminomethyl)-                                                        phenyl                                                  199  SC(S)NR'R  CH.sub.3                                                                              3-(methoxyiminomethyl)-                                                        phenyl                                                  200  SC(S)NR'R  CH.sub.3                                                                              4-(methoxyiminomethyl)-                                                        phenyl                                                  201  SC(S)NR'R  CH.sub.3                                                                              2-(ethoxyiminomethyl)-                                                         phenyl                                                  202  SC(S)NR'R  CH.sub.3                                                                              3-(ethoxyiminomethyl)-                                                         phenyl                                                  203  SC(S)NR'R  CH.sub.3                                                                              4-(ethoxyiminomethyl)-                                                         phenyl                                                  204  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    methoximinoethyl-                                                              phenyl                                                  205  SC(S)NR'R  CH.sub.3                                                                              2-methyl-4-                                                                    methoximinomethyl-                                                             phenyl                                                  206  SC(S)NR'R  CH.sub.3                                                                              2,6-dimethyl-4-                                                                methoximinomethyl-                                                             phenyl                                                  207  SC(S)NR'R  CH.sub.3                                                                              2,6-dimethyl-4-                                                                methoximinoethyl-                                                              phenyl                                                  208  SC(S)NR'R  CH.sub.3                                                                              2-phenylphenyl                                          209  SC(S)NR'R  CH.sub.3                                                                              3-phenylphenyl                                          210  SC(S)NR'R  CH.sub.3                                                                              4-phenylphenyl                                          211  SC(S)NR'R  CH.sub.3                                                                              2-phenoxyphenyl                                         212  SC(S)NR'R  CH.sub.3                                                                              3-phenoxyphenyl                                         213  SC(S)NR'R  CH.sub.3                                                                              4-phenoxyphenyl                                         214  SC(S)NR'R  CH.sub.3                                                                              2-benzyloxyphenyl                                       215  SC(S)NR'R  CH.sub.3                                                                              3-benzyloxyphenyl                                       216  SC(S)NR'R  CH.sub.3                                                                              4-benzyloxyphenyl                                       217  SC(S)NR'R  CH.sub.3                                                                              4-(imidazol-1'-yl)phenyl                                218  SC(S)NR'R  CH.sub.3                                                                              4-(piperazin-1'-yl)phenyl                               219  SC(S)NR'R  CH.sub.3                                                                              4-(morpholin-1'-yl)-                                                           phenyl                                                  220  SC(S)NR'R  CH.sub.3                                                                              4-(piperidin-1'-yl)phenyl                               221  SC(S)NR'R  CH.sub.3                                                                              4-(pyridyl-2'-oxy)phenyl                                222  SC(S)NR'R  CH.sub.3                                                                              2-cyclopropylphenyl                                     223  SC(S)NR'R  CH.sub.3                                                                              3-cyclopropylphenyl                                     224  SC(S)NR'R  CH.sub.3                                                                              4-cyclopropylphenyl                                     225  SC(S)NR'R  CH.sub.3                                                                              3-cyclohexylphenyl                                      226  SC(S)NR'R  CH.sub.3                                                                              4-cyclohexylphenyl                                      227  SC(S)NR'R  CH.sub.3                                                                              4-oxiranylphenyl                                        228  SC(S)NR'R  CH.sub.3                                                                              4-(1',3'-dioxan-2'-yl)-                                                        phenyl                                                  229  SC(S)NR'R  CH.sub.3                                                                              4-(tetrahydropyran-2-yl-                                                       oxy)-phenyl                                             230  SC(S)NR'R  CH.sub.3                                                                              1-naphthyl                                              231  SC(S)NR'R  CH.sub.3                                                                              2-naphthyl                                              232  SC(S)NR'R  CH.sub.3                                                                              benzyl                                                  233  SC(S)NR'R  CH.sub.3                                                                              2-methylbenzyl                                          234  SC(S)NR'R  CH.sub.3                                                                              3-methylbenzyl                                          235  SC(S)NR'R  CH.sub.3                                                                              4-methylbenzyl                                          236  SC(S)NR'R  CH.sub.3                                                                              4-tert.-butylbenzyl                                     237  SC(S)NR'R  CH.sub.3                                                                              2-chlorobenzyl                                          238  SC(S)NR'R  CH.sub.3                                                                              3-chlorobenzyl                                          239  SC(S)NR'R  CH.sub.3                                                                              4-chlorobenzyl                                          240  SC(S)NR'R  CH.sub.3                                                                              2-pyridyl                                               241  SC(S)NR'R  CH.sub.3                                                                              3-pyridyl                                               242  SC(S)NR'R  CH.sub.3                                                                              4-pyridyl                                               243  SC(S)NR'R  CH.sub.3                                                                              2,6-pyrimidinyl                                         244  SC(S)NR'R  CH.sub.3                                                                              1,5-pyrimidinyl                                         245  SC(S)NR'R  CH.sub.3                                                                              2-thienyl                                               246  SC(S)NR'R  CH.sub.3                                                                              3-thienyl                                               247  SC(S)NR'R  CH.sub.3                                                                              2-furyl                                                 248  SC(S)NR'R  CH.sub.3                                                                              3-furyl                                                 249  SC(S)NR'R  CH.sub.3                                                                              1-pyrrolyl                                              250  SC(S)NR'R  CH.sub.3                                                                              1-imidazolyl                                            251  SC(S)NR'R  CH.sub.3                                                                              1,2,4-triazolyl                                         252  SC(S)NR'R  CH.sub.3                                                                              1,3,4-triazolyl                                         253  SC(S)NR'R  CH.sub.3                                                                              4-thiazolyl                                             254  SC(S)NR'R  CH.sub.3                                                                              2-benzothiazolyl                                        255  SC(S)NR'R  CH.sub.3                                                                              2-pyridylmethyl                                         256  SC(S)NR'R  CH.sub.3                                                                              3-pyridylmethyl                                         257  SC(S)NR'R  CH.sub.3                                                                              4-pyridylmethyl                                         258  SC(S)NR'R  Et     phenyl                                                  259  SC(S)NR'R  Et     2-methylphenyl                                          260  SC(S)NR'R  Et     2-chlorophenyl                                          261  SC(S)NR'R  Et     4-methylphenyl                                          262  SC(S)NR'R  Et     2-naphtyl                                               263  SC(S)SR    --     CH.sub.3                                                264  SC(S)SR    --     CH.sub.2 -phenyl                                        265  SC(S)SR    --     phenyl                                                  266  SC(S)SR    --     A*                                                      267  SC(S)OR    --     CH.sub.3                                                268  SC(S)OR    --     phenyl                                                  269  SC(S)OR    --     2-CH.sub.3 -phenyl                                      270  SC(S)OR    --     3-CH.sub.3 -phenyl                                      271  SC(S)OR    --     4-CH.sub.3 -phenyl                                      272  SC(S)OR    --     2-Cl-phenyl                                             273  SC(S)OR    --     3-Cl-phenyl                                             274  SC(S)OR    --     4-Cl-phenyl                                             275  SC(S)OR    --     CH.sub.2 -phenyl                                        276  SC(S)OR    --     CH.sub.2(2-Me)-phenyl                                   277  SC(S)OR    --     CH.sub.2(3-Me)-phenyl                                   278  SC(S)OR    --     CH.sub.2(4-Me)-phenyl                                   279  SC(S)OR    --     CH.sub.2(2-Cl)-phenyl                                   280  SC(S)OR    --     CH.sub.2(3-Cl)phenyl                                    281  SC(S)OR    --     CH.sub.2(4-Cl)phenyl                                    282  OC(O)OR    --     CH.sub.3                                                283  OC(O)OR    --     tert.-butyl                                             284  OC(O)OR    --     CH.sub.2 -phenyl                                        285  OC(O)OR    --     phenyl                                                  286  SC(S)NR'R  CH.sub.3                                                                              3-Me, 4-F-phenyl                                        ______________________________________                                          ##STR22##                                                                      .sup.a) IR (cm.sup.-1); .sup.1 HNMR (CDCl.sub.3 /TMS); m. p.             

                                      TABLE 4                                      __________________________________________________________________________      ##STR23##                                                                     No.                                                                               D      R' R                   phys. data.sup.a)                             __________________________________________________________________________     1  SC(S)NR'R                                                                             CH.sub.3                                                                          methyl                                                            2  SC(S)NR'R                                                                             CH.sub.3                                                                          ethyl                                                             3  SC(S)NR'R                                                                             CH.sub.3                                                                          n-propyl                                                          4  SC(S)NR'R                                                                             CH.sub.3                                                                          tert.-butyl                                                       5  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclopropyl                                                       6  SC(S)NR'R                                                                             CH.sub.3                                                                          cyclohexyl                                                        7  SC(S)NR'R                                                                             CH.sub.3                                                                          methoxymethyl                                                     8  SC(S)NR'R                                                                             CH.sub.3                                                                          phenoxymethyl                                                     9  SC(S)NR'R                                                                             CH.sub.3                                                                          methylthiomethyl                                                  10 SC(S)NR'R                                                                             CH.sub.3                                                                          phenyl                                                            11 SC(S)NR'R                                                                             CH.sub.3                                                                          2-fluorophenyl                                                    12 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluorophenyl                                                    13 SC(S)NR'R                                                                             CH.sub.3                                                                          4-flourophenyl      152-156° C.                            14 SC(S)NR'R                                                                             CH.sub.3                                                                          pentafluorophenyl                                                 15 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorophenyl                                                    16 SC(S)NR'R                                                                             CH.sub.3                                                                          3-chlorophenyl      2.90(d, 3H), 3.71, 3.89(2×3H),                                           4.35                                                                           (2H), 6.72(1H), 7.10-7.46(8H)                 17 SC(S)NR'R                                                                             CH.sub.3                                                                          4-chlorophenyl                                                    18 SC(S)NR'R                                                                             CH.sub.3                                                                          pentachlorophenyl                                                 19 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3-dichlorophenyl                                                20 SC(S)NR'R                                                                             CH.sub.3                                                                          2,,4-dichlorophenyl                                               21 SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dichlorophenyl                                                22 SC(S)NR' R                                                                            CH.sub.3                                                                          2,6-dichlorophenyl                                                23 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dichlorophenyl                                                24 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dichlorophenyl                                                25 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trichlorophenyl                                             26 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trichlorophenyl                                             27 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trichlorophenyl                                             28 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             29 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichlorophenyl                                             30 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trichlorophenyl                                             31 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         32 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         33 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     34 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     35 SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     36 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 37 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-florophenyl                                             38 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           39 SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      40 SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      41 SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      42 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           43 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           44 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-6-fluorophenyl                                           45 SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            46 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            47 SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-flourophenyl                                            48 SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            49 SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-flourophenyl                                           50 SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           51 SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     52 SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     53 SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     54 SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     55 SC(S)NR'R                                                                             CH.sub. 3                                                                         3-nitrophenyl                                                     56 SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     57 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl                                                    58 SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl      2.36; 3.74; 3.88(3×3H); 2.90(d,                                          3H);                                                                           4.34(2H); 6.69(1H); 7.02-7.47(8H)             59 SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl      2.35; 3.72; 3.88(3×3H); 2.89(d,                                          3H);                                                                           4.32(2H); 6.67(1H); 7.05-7.43(8H)             60 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                61 SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl                                                62 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                63 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                64 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             65 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             66 SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             67 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             68 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             69 SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethylphenyl                                             70 SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 71 SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     72 SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     73 SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     74 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 75 SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  76 SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  77 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-propylphenyl                                                  78 SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropylphenyl                                                 79 SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropylphenyl                                                 80 SC(S)NR'R                                                                             CH.sub.3                                                                          4-isopropylphenyl                                                 81 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-diisopropylphenyl                                             82 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diisopropylphenyl                                             83 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-butyphenyl                                                    84 SC(S)NR' R                                                                            CH.sub.3                                                                          4-sec.-butylphenyl                                                85 SC(S)NR'R                                                                             CH.sub.3                                                                          4-iso-butylphenyl                                                 86 SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylphenyl                                               87 SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butylphenyl                                               88 SC(S)NR'R                                                                             CH.sub.3                                                                          2-tert.-butylphenyl                                               89 SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-di-tert.-butylphenyl                                          90 SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-di-tert.-butylphenyl                                          91 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-hexylphenyl                                                   92 SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-dodecylphenyl                                                 93 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-tert.-butylphenyl                                      94 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-tert.-butylphenyl                                      95 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropylphenyl                                        96 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-cyclohexylphenyl                                       97 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenylphenyl                                           98 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzylphenyl                                           99 SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-phenoxyphenyl                                          100                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-benzyloxyphenyl                                        101                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-chlorophenyl                                           102                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-chlorophenyl                                           103                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-chlorophenyl                                           104                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-chlorophenyl                                           105                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-fluorophenyl                                           106                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-bromophenyl                                            107                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-bromophenyl                                            108                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-3-methoxyphenyl                                          109                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoxyphenyl                                          110                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-5-methoxyphenyl                                          111                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-6-methoxyphenyl                                          112                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-isopropoxyphenyl                                       113                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-2,5-dimethoxyphenyl                                      114                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methoxyphenyl                                                   115                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methoxyphenyl                                                   116                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methoxyphenyl                                                   117                                                                               SC(S)NR'R                                                                             CH.sub. 3                                                                         2,3-dimethoxyphenyl                                               118                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethoxyphenyl                                               119                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,5-dimethoxyphenyl                                               120                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethoxyphenyl                                               121                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethoxyphenyl                                               122                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethoxyphenyl                                               123                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,6-dimethoxyphenyl                                               124                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethoxyphenyl                                            125                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethoxyphenyl                                            126                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethoxyphenyl                                            127                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trichlorophenyl                                             128                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trichloroyphenyl                                            129                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4,6-tetrachlorophenyl                                         130                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5,6-tetrachlorophenyl                                         131                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromophenyl                                                     132                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromophenyl                                                     133                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-bromophenyl                                                     134                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dibromophenyl                                                 135                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-fluorophenyl                                            136                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-methoxyphenyl                                           137                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-iodophenyl                                                      138                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-iodophenyl                                                      139                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-iodophenyl                                                      140                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-fluorophenyl                                           141                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-5-fluorophenyl                                           142                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-6-fluorophenyl                                           143                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloro-4-bromophenyl                                            144                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-chlorophenyl                                            145                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-bromo-4-fluorophenyl                                            146                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-bromo-4-chlorophenyl                                            147                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloro-4-fluorophenyl                                           148                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-fluoro-4-chlorophenyl                                           149                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyanophenyl                                                     150                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyanophenyl                                                     151                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyanophenyl                                                     152                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-nitrophenyl                                                     153                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-nitrophenyl                                                     154                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-nitrophenyl                                                     155                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylphenyl                                                    156                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylphenyl                                                    157                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylphenyl                                                    158                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4-dimethylphenyl                                                159                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethylphenyl                                                160                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4-dimethylphenyl                                                161                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-dimethylphenyl                                                162                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,4-trimethylphenyl                                             163                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,5-trimethylphenyl                                             164                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,3,6-trimethylphenyl                                             165                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             166                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethylphenyl                                             167                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethylphenyl                                             168                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          pentamethylphenyl                                                 169                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethylphenyl                                                     170                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethylphenyl                                                     171                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethylphenyl                                                     172                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,5-diethylphenyl                                                 173                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-n-propylphenyl                                                  174                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-n-propylphenyl                                                  175                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-n-propylphenyl                                                  176                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,5-trimethoxyphenyl                                            177                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,4,6-trimethoxyphenyl                                            178                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3,4,5-trimethoxyphenyl                                            179                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-ethoxyphenyl                                                    180                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-ethoxyphenyl                                                    181                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-ethoxyphenyl                                                    182                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-isopropoxyphenyl                                                183                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-isopropoxyphenyl                                                184                                                                               SC(S)NR' R                                                                            CH.sub.3                                                                          4-isopropoxyphenyl                                                185                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-tert.-butoxyphenyl                                              186                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butoxyphenyl                                              187                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethoxyphenyl                                          188                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethoxyphenyl                                          189                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethoxyphenyl                                          190                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(1',1',2',2'-tetrafluoro)-ethoxyphenyl                          191                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',1',2',2'-tetrafluoro)-ethoxyphenyl                          192                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chloromethylphenyl                                              193                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chloromethylphenyl                                              194                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-chloromethylphenyl                                              195                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-trifluoromethylphenyl                                           196                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-trifluoromethylphenyl                                           197                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-trifluoromethylphenyl                                           198                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(methoxyiminomethyl)-phenyl                                     199                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(methoxyiminomethyl)-phenyl                                     200                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(methoxyiminomethyl)-phenyl                                     201                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-(ethoxyiminomethyl)-phenyl                                      202                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-(ethoxyiminomethyl)-phenyl                                      203                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(ethoxyiminomethyl)-phenyl                                      204                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinoethyl-phenyl                                205                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methyl-4-methoximinomethyl-phenyl                               206                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximinomethyl-phenyl                           207                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-dimethyl-4-methoximinoethyl-phenyl                            208                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenylphenyl                                                    209                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-phenylphenyl                                                    210                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenylphenyl                                                    211                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-phenoxyphenyl                                                   212                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-phenoxyphenyl                                                   213                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-phenyoxphenyl                                                   214                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzyloxyphenyl                                                 215                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-benzyloxyphenyl                                                 216                                                                               SC(S)NR' R                                                                            CH.sub.3                                                                          4-benzyloxyphenyl                                                 217                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(imidazol-1'-yl)phenyl                                          218                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperazin-1'-yl)phenyl                                         219                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(morpholin-1'-yl)phenyl                                         220                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(piperidin-1'-yl)phenyl                                         221                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(pyridyl-2'-oxy)phenyl                                          222                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-cyclopropylphenyl                                               223                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclopropylphenyl                                               224                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclopropylphenyl                                               225                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-cyclohexylphenyl                                                226                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-cyclohexylphenyl                                                227                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-oxiranylphenyl                                                  228                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(1',3'-dioxan-2'-yl)-phenyl                                     229                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-(tetrahydropyran-2-yl-oxy)-phenyl                               230                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-naphthyl                                                        231                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-naphthyl                                                        232                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          benzyl                                                            233                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-methylbenzyl                                                    234                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-methylbenzyl                                                    235                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-methylbenzyl                                                    236                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-tert.-butylbenzyl                                               237                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-chlorobenzyl                                                    238                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-chlorobenzyl                                                    239                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-chlorobenzyl                                                    240                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridyl                                                         241                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridyl                                                         242                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridyl                                                         243                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2,6-pyrimidinyl                                                   244                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,5-pyrimidinyl                                                   245                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-thienyl                                                         246                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-thienyl                                                         247                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-furyl                                                           248                                                                               SC(S)NR' R                                                                            CH.sub.3                                                                          3-furyl                                                           249                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-pyrrolyl                                                        250                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1-imidazolyl                                                      251                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,2,4-triazolyl                                                   252                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          1,3,4-triazolyl                                                   253                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-thiazolyl                                                       254                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-benzothiazolyl                                                  255                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          2-pyridylmethyl                                                   256                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-pyridylmethyl                                                   257                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          4-pyridylmethyl                                                   258                                                                               SC(S)NR'R                                                                             Et phenyl              162° C.                                259                                                                               SC(S)NR'R                                                                             Et 2-methylphenyl                                                    260                                                                               SC(S)NR'R                                                                             Et 2-chlorophenyl                                                    261                                                                               SC(S)NR'R                                                                             Et 4-methylphenyl      1663, 1523, 1508, 1444, 1399, 1385,                                            1272, 1103, 1038                              262                                                                               SC(S)NR'R                                                                             Et 2-naphthyl                                                        263                                                                               SC(S)SR                                                                               -- CH.sub.3                                                          264                                                                               SC(S)SR                                                                               -- CH.sub.2 -phenyl                                                  265                                                                               SC(S)SR                                                                               -- phenyl                                                            266                                                                               SC(S)SR                                                                               -- A*                                                                267                                                                               SC(S)OR                                                                               -- CH.sub.3                                                          268                                                                               SC(S)OR                                                                               -- phenyl                                                            269                                                                               SC(S)OR                                                                               -- 2-CH.sub.3 -phenyl                                                270                                                                               SC(S)OR                                                                               -- 3-CH.sub.3 -phenyl                                                271                                                                               SC(S)OR                                                                               -- 4-CH.sub.3 -phenyl                                                272                                                                               SC(S)OR                                                                               -- 2-Cl-phenyl                                                       273                                                                               SC(S)OR                                                                               -- 3-Cl-phenyl                                                       274                                                                               SC(S)OR                                                                               -- 4-Cl-phenyl                                                       275                                                                               SC(S)OR                                                                               -- CH.sub.2 -phenyl                                                  276                                                                               SC(S)OR                                                                               -- CH.sub.2(2-Me)-phenyl                                             277                                                                               SC(S)OR                                                                               -- CH.sub.2(3-Me)-phenyl                                             278                                                                               SC(S)OR                                                                               -- CH.sub.2(4-Me)-phenyl                                             279                                                                               SC(S)OR                                                                               -- CH.sub.2(2-Cl)-phenyl                                             280                                                                               SC(S)OR                                                                               -- CH.sub.2(3-Cl)phenyl                                              281                                                                               SC(S)OR                                                                               -- CH.sub.2(4-Cl)phenyl                                              282                                                                               OC(O)OR                                                                               -- CH.sub.3                                                          283                                                                               OC(O)OR                                                                               -- tert.-butyl                                                       284                                                                               OC(O)OR                                                                               -- CH.sub.2 -phenyl                                                  285                                                                               OC(O)OR                                                                               -- phenyl              5.13 ppm (CH.sub.2)                           286                                                                               SC(S)NR'R                                                                             CH.sub.3                                                                          3-Me, 4-F-phenyl    2.29; 3.73; 3.90(3×3H), 2.92(d,                                          3H),                                                                           4.35 2H), 6.70(1H), 6.98-7.46(7H)             287                                                                               OC(O)NR'R                                                                             H  i-propyl            138-140° C.                            288                                                                               OC(O)NR'R                                                                             H  tert.-butyl         143-145° C.                            289                                                                               OC(O)NR'R                                                                             H                                                                                  ##STR24##          117-119° C.                            290                                                                               OC(O)NR'R                                                                             H  2-Me-phenyl         140-141° C.                            291                                                                               OC(O)NR'R                                                                             H  3-Me-phenyl         150-152° C.                            292                                                                               OC(O)NR'R                                                                             H  4-Me-phenyl         204-205° C.                            293                                                                               OC(O)NR'R                                                                             H  4-F-phenyl          136-139° C.                            294                                                                               OC(O)NR'R                                                                             H  2,6-Cl.sub.2 -phenyl                                                                               195-198° C.                            295                                                                               OC(O)NR'R                                                                             H  3,5-Cl.sub.2 -phenyl                                                                               162-164° C.                            __________________________________________________________________________      ##STR25##                                                                      .sup.a) IR (cm.sup.-1); .sup.1 HNMR (CDCl.sub.3 /TMS); m. p.             

The novel compounds are suitable as fungicides.

The fungicidal compounds, or agents containing them, may be applied for instance in the form of directly sprayable solutions, powders, suspensions (including high-percentage aqueous, oily or other suspensions), dispersions, emulsions, oil dispersions, pastes, dusts, broadcasting agents, or granules by spraying, atomizing, dusting, broadcasting or watering. The forms of application depend entirely on the purpose for which the agents are being used, but they must ensure as fine a distribution of the active ingredients according to the invention as possible.

Normally, the plants are sprayed or dusted with the active ingedients or the seeds of the plants are treated with the active ingredients.

The formulations are produced in known manner, for example by extending the active ingredient with solvents and/or carriers, with or without the use of emulsifiers and dispersants; if water is used as solvent, it is also possible to employ other organic solvents as auxiliary solvents. Suitable auxiliaries for this purpose are solvents such as aromatics (e.g., xylene), chlorinated aromatics (e.g., chlorobenzenes), paraffins (e.g., crude oil fractions), alcohols (e.g., methanol, butanol), ketones (e.g., cyclohexanone), amines (e.g., ethanolamine, dimethylformamide), and water; carriers such as ground natural minerals (e.g., kaolins, aluminas, talc and chalk) and ground synthetic minerals (e.g., highly disperse silica and silicates); emulsifiers such as nonionic and anionic emulsifiers (e.g., polyoxyethylene fatty alcohol ethers, alkyl sulfonates and aryl sulfonates); and dispersants such as lignin-sulfite waste liquors and methylcellulose.

Examples of surfactants are: alkali metal, alkaline earth metal and ammonium salts of aromatic sulfonic acids, e.g., ligninsulfonic acid, phenolsulfonic acid, naphthalenesulfonic acid and dibutylnaphthalenesulfonic acid, and of fatty acids, alkyl and alkylaryl sulfonates, and alkyl, lauryl ether and fatty alcohol sulfates, and salts of sulfated hexadecanols, heptadecanols, and octadecanols, salts of fatty alcohol glycol ethers, condensation products of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensation products of naphthalene or naphthalenesulfonic acids with phenol and formaldehyde, polyoxyethylene octylphenol ethers, ethoxylated isooctylphenol, ethoxylated octylphenol and ethoxylated nonylphenol, alkylphenol polyglycol ethers, tributylphenyl polyglycol ethers, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, lignin-sulfite waste liquors and methyl cellulose.

Powders, dusts and broadcasting agents may be prepared by mixing or grinding the active ingredients with a solid carrier.

Granules, e.g., coated, impregnated or homogeneous granules, may be prepared by bonding the active ingredients to solid carriers. Examples of solid carriers are mineral earths such as silicic acids, silica gels, silicates, talc, kaolin, attapulgus clay, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground plastics, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, and ureas, and vegetable products such as grain meals, bark meal, wood meal, and nutshell meal, cellulosic powders, etc.

Examples of such formulations are given below.

I. A solution of 90 parts by weight of compound no. 16 from Table 4 and 10 parts by weight of N-methyl-α-pyrrolidone, which is suitable for application in the form of very fine drops.

II. A mixture of 20 parts by weight of compound no. 58 from Table 4, 80 parts by weight of xylene, 10 parts by weight of the adduct of 8 to 10 moles of ethylene oxide and 1 mole of oleic acid-N-monoethanolamide, 5 parts by weight of the calcium salt of dodecylbenzenesulfonic acid, and 5 parts by weight of the adduct of 40 moles of ethylene oxide and 1 mole of castor oil. By finely dispersing the mixture in water, an aqueous dispersion is obtained.

III. An aqueous dispersion of 20 parts by weight of compound no. 59 from Table 4, 40 parts by weight of cyclohexanone, 30 parts by weight of isobutanol, 20 parts by weight of the adduct of 40 moles of ethylene oxide and 1 mole of castor oil.

IV. An aqueous dispersion of 20 parts by weight of compound no. 157 from Table 4, 25 parts by weight of cyclohexanol, 65 parts by weight of a mineral oil fraction having a boiling point between 210° and 280° C., and 10 parts by weight of the adduct of 40 moles of ethylene oxide and 1 mole of castor oil.

V. A hammer-milled mixture of 80 parts by weight of compound no. 286 from Table 4, 3 parts by weight of the sodium salt of diisobutylnaphthalene-α-sulfonic acid, 10 parts by weight of the sodium salt of a lignin-sulfonic acid obtained from a sulfite waste liquor, and 7 parts by weight of powdered silica gel. By finely dispersing the mixture in 20,000 parts by weight of water, a spray liquor is obtained.

VI. An intimate mixture of 3 parts by weight of compound no. 16 from Table 4 and 97 parts by weight of particulate kaolin. The dust contains 3wt % of the active ingredient.

VII. An intimate mixture of 30 parts by weight of compound no. 58 from Table 4, 92 parts by weight of powdered silica gel and 8 parts by weight of paraffin oil sprayed onto the surface of this silica gel. This formulation of the active ingredient exhibits good adherence.

VIII. A stable aqueous dispersion of 40 parts by weight of compound no. 59 from Table 4, 10 parts of the sodium salt of a phenolsulfonic acid-urea-formaldehyde condensate, 2 parts of silica gel and 48 parts of water, which dispersion can be further diluted.

IX. A stable oily dispersion of 20 parts by weight of compound no. 157 from Table 4, 2 parts by weight of the calcium salt of dodecylbenzenesulfonic acid, 8 parts by weight of a fatty alcohol polyglycol ether, 2 parts by weight of the sodium salt of a phenolsulfonic acid-urea-formaldehyde condensate and 68 parts by weight of a paraffinic mineral oil.

The novel compounds are extremely effective on a broad spectrum of phytopathogenic fungi, in particular those from the class consisting of the Ascomycetes and Basidiomycetes. Some of them have a remarkably high systemic mobility and action after application to the soil and particularly to foliage.

The fungicidal con, pounds are of particular interest for controlling a large number of fungi in various crops or their seeds, especially wheat, rye, barley, oats, rice, Indian corn, lawns, cotton, soybeans, coffee, sugar cane, fruit and ornamentals in horticulture and viticulture, and in vegetables such as cucumbers, beans and cucurbits.

The compounds are applied by treating the seeds, plants, materials or soil to be protected against fungus attack with a fungicidally effective amount of the active ingredients.

The compounds may be applied before or after infection of the materials, plants or seeds by the fungi.

The compounds I are particularly useful for controlling the following plant diseases:

Erysiphe graminis in cereals,

Erysiphe cichoracearum and Sphaerotheca fuliginea in cucurbits,

Podosphaera leucotricha in apples,

Uncinula necator in vines,

Puccinia species in cereals,

Rhizoctonia solani in cotton,

Ustilago species in cereals and sugar cane,

Venturia inaegualis (scab) in apples,

Helminthosporium species in cereals,

Septoria nodorum in wheat,

Botrytis cinerea (gray mold) in strawberries and grapes,

Cercospora arachidicola in groundnuts,

Pseudocercosporella herpotrichoides in wheat and barley,

Pyricularia oryzae in rice,

Phytophthora infestans in potatoes and tomatoes,

Fusarium and Verticillium species in various plants,

Plasmopara viticola in grapes,

Alternaria species in fruit and vegetables.

The novel compounds may also be used for protecting materials (timber), for example against Paecilomyces variotii.

The fungicidal agents generally contain from 0.1 to 95, and preferably from 0.5 to 90, wt % of active ingredient.

The application rates depend on the type of effect desired, but are generally from 0.02 to 3 kg of active ingredient per hectare.

When the active ingredients are used for treating seed, application rates of from 0.001 to 50, and preferably from 0.01 to 10, g per kg of seed are generally required.

When the agents according to the invention are used as fungicides, they may be employed together with other active ingredients, e.g., herbicides, insecticides, growth regulators, other fungicides and fertilizers.

When admixed with other fungicides, the spectrum of fungicidal action is in many instances increased.

USE EXAMPLES

The active ingredients used for comparison purposes were methyl α-[2-(phenylthiomethyl)-phenyl]-β-methoxyacrylate (A) and methyl 2-(phenylthiomethyl)-α-methoxyimino-phenylacetate (B).

USE EXAMPLE 1

Action on wheat mildew

Leaves of pot-grown wheat seedlings of the "Fruhgold" variety were sprayed with aqueous liquors containing (dry basis) 80% of active ingredient and 20% of emulsifier, and dusted, 24 hours after the sprayed-on layer had dried, with spores of wheat mildew (Erysiphe graminis var. tritici). The plants were then set up in the greenhouse at from 20° to 22° C. and a relative humidity of from 75 to 80%. The extent of mildew spread was assessed after 7 days.

The results show that active ingredient no. 16 from Table 1 has, when applied as a spray liquor containing 63 ppm of active ingredient, a better fungicidal action (15% leaf attack) than prior art comparative agent A (40% leaf attack).

USE EXAMPLE 2

Action on Plasmopara viticola

Leaves of potted vines of the Muller-Thurgau variety were sprayed with aqueous suspensions containing (dry basis) 80% of active ingredient and 20% of emulsifier. To assess the duration of action, the plants were-set up, after the sprayed-on layer had dried, for 8 days in the greenhouse. Then the leaves were infected with a zoospore suspension of Plasmopara viticola. The plants were first placed for 48 hours in a water vapor-saturated chamber at 24° C. and then in a greenhouse for 5 days at from 20° to 30° C. To accelerate and intensify the sporangiophore discharge, the plants were then again placed in the moist chamber for 16 hours. The extent of fungus attack was then assessed on the undersides of the leaves.

The results show that active ingredient no. 13 from Table 2 has, when applied as a spray liquor containing 63 ppm of active ingredient, a better fungicidal action (15% leaf attack) than prior art active ingredient B (40% leaf attack). 

We claim:
 1. A benzyl compound of the formula I ##STR26## where A is CH--C₁ -C₄ -alkyl,B is OH, C₁ -C₄ -alkylthio, C₁ -C₄ -alkoxy or C₁ -C₄ -alkylamino, U, V and W are identical or different and are each hydrogen, halogen, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy, D is ##STR27## where R' is hydrogen or C₁ -C₄ -alkyl and R is hydrogen, C₁ -C₁₀ -alkyl, C₃ -C₆ -cycloalkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -halocycloalkyl, C₃ -C₆ -cycloalkyl-C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl, unsubstituted or substituted arylthio-C₁ -C₄ -alkyl, unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryl, unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl or unsubstituted or substituted heterocyclyl, substituents being halogen, cyano, CO₂ (C₁ -C₄ -alkyl), CO(C₁ -C₄ -alkyl), nitro, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy, C₁ -C₄ -alkoximino-C₁ - or C₂ -alkyl, aryl, aryloxy, benzyloxy, hetaryl, hetaryloxy, C₃ -C₆ -cycloalkyl, heterocyclyl or heterocyclyloxy.
 2. A benzyl compound of the formula I as claimed in claim 1, wherein A is CH-methyl, B is methoxy and U, V, W and D have the meanings stated in claim
 1. 3. A fungicide containing an inert carrier and a fungicidal amount of a benzyl compound of the formula ##STR28## where A is CH--C₁ -C₄ -alkyl,B is ON, C₁ -C₄ -alkylthio, C₁ -C₄ -alkoxy or C₁ -C₄ -alkylamino, U, V and W are identical or different and are each hydrogen, halogen, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy, D is ##STR29## where R' is hydrogen or C₁ -C₄ -alkyl and R is hydrogen, C₁ -C₁₀ -alkyl, C₃ -C₆ -cycloalkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -halocycloalkyl, C₃ -C₆ -cycloalkyl-C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl, unsubstituted or substituted arylthio-C₁ -C₄ -alkyl, unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryl, unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl or unsubstituted or substituted heterocyclyl, substituents being halogen, cyano, CO₂ (C₁ -C₄ -alkyl) , CO(C₁ -C₄ -alkyl), nitro, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy, C₁ -C₄ -alkoximino-C₁ - or C₂ -alkyl, aryl, aryloxy, benzyloxy, hetaryl, hetaryloxy, C₃ -C₆ -cycloalkyl, heterocyclyl or heterocyclyloxy.
 4. A method for controlling fungi, wherein the fungi or the materials, plants or seed threatened by fungal attack or the soil is or are treated with a fungicidal amount of a compound of the formula I ##STR30## where A is CH--C₁ -C₄ -alkyl,B is OH, C₁ -C₄ -alkylthio, C₁ -C₄ -alkoxy or C₁ -C₄ -alkylamino, U, V and W are identical or different and are each hydrogen, halogen, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy, D is ##STR31## where R' is hydrogen or C₁ -C₄ -alkyl and R is hydrogen, C₁ -C₁₀ -alkyl, C₃ -C₆ -cycloalkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -halocycloalkyl, C₃ -C₆ -cycloalkyl-C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl, unsubstituted or substituted arylthio-C₁ -C₄ -alkyl, unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryl, unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl or unsubstituted or substituted heterocyclyl, substituents being halogen, cyano, CO₂ (C₁ -C₄ -alkyl), CO(C₁ -C₄ -alkyl), nitro, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy, C₁ -C₄ -alkoximino-C₁ - or C₂ -alkyl, aryl, aryloxy, benzyloxy, hetaryl, hetaryloxy, C₃ -C₆ -cycloalkyl, heterocyclyl or heterocyclyloxy.
 5. A method for controlling insects, wherein the insects or the place where the insects are present is or are treated with an insecticidal amount of a compound of the formula I ##STR32## where A is CH₂, or CH--C₁ -C₄ -alkyl,B is OH, C₁ -C₄ -alkylthio, C₁ -C₄ -alkoxy or C₁ -C₄ -alkylamino, U, V and W are identical or different and are each hydrogen, halogen, C₁ -C₄ -alkyl or C₁ -C₄ -alkoxy, D is ##STR33## where R' is hydrogen or C₁ -C₄ -alkyl and R is hydrogen, C₁ -C₁₀ -alkyl, C₃ -C₆ -cycloalkyl, C₁ -C₄ -haloalkyl, C₃ -C₆ -halocycloalkyl, C₃ -C₆ -cycloalkyl-C₁ -C₆ -alkyl, C₁ -C₄ -alkoxy-C₁ -C₄ -alkyl, C₁ -C₄ -alkylthio-C₁ -C₄ -alkyl, unsubstituted or substituted arylthio-C₁ -C₄ -alkyl, unsubstituted or substituted aryloxy-C₁ -C₄ -alkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryl, unsubstituted or substituted hetaryl-C₁ -C₄ -alkyl, unsubstituted or substituted hetaryloxy-C₁ -C₄ -alkyl or unsubstituted or substituted heterocyclyl, substituents being halogen, cyano, CO₂ (C₁ -C₄ -alkyl), CO(C₁ -C₄ -alkyl), nitro, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄ -haloalkyl, C₁ -C₄ -haloalkoxy, C₁ -C₄ -alkoximino-C₁ - or C₂ -alkyl, aryl, aryloxy, benzyloxy, hetaryl, hetaryloxy, C₃ -C₆ -cycloalkyl, heterocyclyl or heterocyclyloxy.
 6. A benzyl compound of the formula I as claimed in claim 1, wherein D is ##STR34##
 7. A benzyl compound of the formula I as claimed in claim 1, wherein D is ##STR35##
 8. A fungicide as claimed in claim 3, wherein D is ##STR36##
 9. A fungicide as claimed in claim 3, wherein D is ##STR37##
 10. A method for controlling fungi as claimed in claim 4, wherein D is ##STR38##
 11. A method for controlling fungi as claimed in claim 4, wherein D is ##STR39##
 12. A method for controlling insects as claimed in claim 5, wherein D is ##STR40##
 13. A method for controlling insects as claimed in claim 5, wherein D is ##STR41## 